121469-00-9

Basic information

• Product Name: (-)-(S)-2-methyl-2-(4-methylphenyl)cyclopentanone
• Synonyms: (-)-(S)-2-methyl-2-(4-methylphenyl)cyclopentanone
• CAS NO: 121469-00-9
• Molecular Weight: 188.269
• Mol File: 121469-00-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (-)-(S)-2-methyl-2-(4-methylphenyl)cyclopentanone(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(S)-2-methyl-2-(4-methylphenyl)cyclopentanone(121469-00-9)
• EPA Substance Registry System: (-)-(S)-2-methyl-2-(4-methylphenyl)cyclopentanone(121469-00-9)

Safety Data

• Hazardous Substances Data: 121469-00-9(Hazardous Substances Data)

Upstream product

• 121402-60-6 (2RS,3S,4S)-4-benzyloxycarbonyl-4-hydroxy-2-methoxycarbonyl-3-methyl-3-p-tolyl-1-cyclopentanone 
• 121468-99-3 (3S,4S)-4-benzyloxycarbonyl-4-hydroxy-3-methyl-3-p-tolyl-1-cyclopentanone 
• 118204-77-6 (+)-4-benzyloxycarbonyl-4-hydroxy-2-methoxycarbonyl-3-methylcyclopent-2-en-1-one 
• 121402-64-0 (1RS,3S,4S)-4-hydroxymethyl-3-methyl-3-p-tolyl-1,4-cyclopentanediol 
• 121402-65-1 (2S,4RS)-4-hydroxy-2-methyl-2-p-tolyl-1-cyclopentanone 
• 15106-88-4 di(p-tolyl)zinc 
• 1071119-43-1 (S)-9-Methyl-9-p-tolyl-1,4-dioxa-spiro[4.4]nonan-6-one 
• 76430-23-4 2-methylcyclopentanone dimethyl acetal 
• 1120-72-5 2-Methylcyclopentanone 
• 624-31-7 4-tolyl iodide 
• 509323-88-0 1-methyl-2-(S)-(2-methyl-cyclopent-1-enyloxymethyl)-pyrrolidine 
• 121402-69-5 (S)-(+)-5-methyl-5-(4-methylphenyl)cyclopent-2-en-1-one 

Downstream Products

• 54750-40-2 1-(1,2-dimethylcyclopent-2-en-1-yl)-4-methylbenzene 
• 16982-00-6 1-(1,2,2-trimethylcyclopentyl)-4-methylbenzene 

Relevant articles and documents

Enantioselective synthesis of 2-alkyl-2-aryl cyclopentanones by asymmetric epoxidation of tetrasubstituted cyclobutylidene olefins and epoxide rearrangement

This letter describes a highly enantioselective epoxidation of tetrasubstituted benzylidenecyclobutanes using glucose-derived ketone as catalyst and oxone as oxidant. The Et2AlCl promoted rearrangement of the resulting epoxides provides 2-alkyl

Enantiopure 2-aryl-2-methyl cyclopentanones by an asymmetric chelation-controlled Heck reaction using aryl bromides: increased preparative scope and effect of ring size on reactivity and selectivity

Quaternary 2-aryl-2-methyl cyclopentanones were obtained in 85-94% ee via Pd(0)-catalyzed chelation-controlled asymmetric arylation of a cyclopentenyl ether with aryl bromides and subsequent hydrolysis. Two new cyclohexenyl ethers were synthesized and evaluated as Heck substrates with both aryl iodides and bromides under different reaction conditions. Arylations of the six-membered vinyl ether 1-methyl-2-(S)-(cyclohex-1-enyloxymethyl)-pyrrolidine with aryl bromides were achieved with t-Bu3P-promoted palladium catalysis using either classical or microwave heating. Isolated Heck products were also obtained in high diastereoselectivities (94-98% de).

A new highly asymmetric chelation-controlled heck arylation

This communication describes the development of a new highly asymmetric chelation-controlled Heck arylation. The methodology permits formation of 2-aryl-2-methyl cyclopentanones in good to very good two-step yields (45-78%) with excellent chiral enrichmen