121492-06-6

Basic information

• Product Name: N-Boc-N-methylethylenediamine
• Synonyms: BOC,ME-EDA;BOC-N-METHYLETHYLENEDIAMINE;BUTTPARK 90\06-19;(2-AMINO-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER;1-BOC-1-METHYL-ETHYLENEDIAMINE;TERT-BUTYL N-(2-AMINOETHYL)-N-METHYLCARBAMATE;N-T-BUTYLOXYCARBONYL-N-METHYL-ETHYLENEDIAMINE;N-TERT-BUTYLOXYCARBONYL-N-METHYL-ETHYLENEDIAMINE
• CAS NO: 121492-06-6
• Molecular Formula: C₈H₁₈N₂O₂
• Molecular Weight: 174.24
• Product Categories: Small molecule;Bifunctional Linkers;Building Blocks;Chemical Biology;Chemical Synthesis;Linkers and Crosslinkers;Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 121492-06-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 248-251 °C (decomp)
• Boiling Point: 79°C/0.4mmHg(lit.)
• Flash Point: >100 °C
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 0.975 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0536mmHg at 25°C
• Refractive Index: n20/D 1.447
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 9.44±0.10(Predicted)
• BRN: 3588326
• CAS DataBase Reference: N-Boc-N-methylethylenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-N-methylethylenediamine(121492-06-6)
• EPA Substance Registry System: N-Boc-N-methylethylenediamine(121492-06-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 2734
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 121492-06-6(Hazardous Substances Data)

Usage

Description

N-Boc-N-methylethylenediamine, also known as Boc-N-Me-en, is an organic compound that serves as a versatile building block in various chemical and pharmaceutical applications. It is a liquid with unique chemical properties that make it suitable for use in organic synthesis and other chemical processes.

Uses

Used in Organic Synthesis:
N-Boc-N-methylethylenediamine is used as a mono-protected building block for the synthesis of various organic compounds. Its ability to protect functional groups during chemical reactions allows for the creation of complex molecules with greater ease and precision.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Boc-N-methylethylenediamine is used as a key intermediate in the development of new drugs. Its unique structure and reactivity make it a valuable component in the synthesis of various pharmaceutical compounds, contributing to the advancement of novel therapeutic agents.
Used in Chemical Processes:
N-Boc-N-methylethylenediamine is also utilized in a range of chemical processes, where its liquid form and chemical properties enable it to act as a catalyst or reagent. This enhances the efficiency and effectiveness of these processes, leading to improved outcomes in various chemical applications.

InChI:InChI=1/C8H18N2O2/c1-8(2,3)12-7(11)10(4)6-5-9/h5-6,9H2,1-4H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 109-81-9 N-methyl-ethane-1,2-diamine 

Downstream Products

• 183444-93-1 ((S)-5-[2-(tert-Butoxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-pentyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 180976-10-7 tert-butyl (2-(((benzyloxy)carbonyl)amino)ethyl)(methyl)carbamate 
• 214976-51-9 {2-[5-[2-(tert-Butoxycarbonyl-methyl-amino)-ethylamino]-7-(4-methoxy-benzyloxy)-6-oxo-6H-1,2,9-triaza-aceanthrylen-2-yl]-ethyl}-(2-hydroxy-ethyl)-carbamic acid tert-butyl ester 
• 294173-07-2 Z-D-Ala-Phe-Lys(Z)-NH-(CH₂)2-N(Me)-Boc 
• 330798-29-3 methyl 4-[({2-[(tert-butoxycarbonyl)(methyl)amino]ethyl}amino)sulphonyl]-3-nitrobenzoate 
• 757967-05-8 methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester 
• 863028-91-5 tert-butyl (2-{[5-(aminocarbonyl)-4-(3-trifluoromethylanilino)pyrimidin-2-yl]amino}ethyl)methylcarbamate 
• 872049-48-4 N-Boc-N-methylaminoethyl-N',N-bis-PNB-guanidine 
• 330798-31-7 methyl 4-[([3-(9-anthryl)propyl]{2-[(tert-butoxycarbonyl)(methyl)amino]ethyl}amino)sulphonyl]-3-nitrobenzoate 
• 630097-75-5 tert-butyl 2-({1-[1-benzyl-5-bromo-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-2-yl]propyl}amino)ethyl(methyl)carbamate 
• 718619-71-7 4'-(2-amino-ethyl)-methyl-carbamic acid tert-butyl ester-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole 
• 882746-03-4 ({2-[(tert-butoxy)-N-methylcarbonylamino]ethyl}amino)-N-[4-methyl-3-(1-{[4-(2,4,5-trifluorophenoxy)phenyl]methyl}(4-piperidyl))phenyl]carboxamide 
• 895133-14-9 [2-(6-benzenesulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylamino)-ethyl]-methyl-carbamic acid tert-butyl ester 

Relevant articles and documents

Cyclization-Activated Prodrugs. Basic Carbamates of 4-Hydroxyanisole

A series of basic carbamates of 4-hydroxyanisole was prepared and evaluated as progenitors of this melanocytotoxic phenol.All of the carbamates were relatively stable at low pH but released 4-hydroxyanisole cleanly at pH 7.4 at rates that were structure dependent.A detailed study of the N-methyl-N-carbamate showed that generation of the parent phenol followed first-order kinetics with t1/2 = 36.3 min at pH 7.4, 37 deg C, and was accompanied by formation of N,N'-dimethylimidazolidinone.These basic carbamates are examples of cyclization-activated prodrugs in which generation of the active drug is not linked to enzymatic cleavage but rather depends solely upon a predictable, intramolecular cyclization-elimination reaction.