1217088-91-9

Basic information

• Product Name: C₁₀H₉NO₃
• CAS NO: 1217088-91-9
• Molecular Weight: 191.186
• Mol File: 1217088-91-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₉NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₉NO₃(1217088-91-9)
• EPA Substance Registry System: C₁₀H₉NO₃(1217088-91-9)

Safety Data

• Hazardous Substances Data: 1217088-91-9(Hazardous Substances Data)

Upstream product

• 148527-38-2 ethyl 3-hydroxy-4-methoxybenzoate 
• 75-05-8 acetonitrile 

Downstream Products

• 1217089-74-1 C₁₀H₁₁N₃O₂ 

Relevant articles and documents

Design, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors

Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatment of asthma and COPD. For this purpose, structure optimization was conducted with the aid of structure-based drug design using the known X-ray crystallography. Also, biological effects of these compounds on the target enzyme were evaluated by using in vitro assays, leading to the potent and selective PDE-4 inhibitor (IC50 10 nM).