1217089-18-3

Basic information

• Product Name: C₉H₈IN₃
• CAS NO: 1217089-18-3
• Molecular Weight: 285.087
• Mol File: 1217089-18-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₉H₈IN₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₉H₈IN₃(1217089-18-3)
• EPA Substance Registry System: C₉H₈IN₃(1217089-18-3)

Safety Data

• Hazardous Substances Data: 1217089-18-3(Hazardous Substances Data)

Upstream product

• 247206-80-0 2-(3-iodobenzoyl)acetonitrile 

Relevant articles and documents

Design, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors

Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatment of asthma and COPD. For this purpose, structure optimization was conducted with the aid of structure-based drug design using the known X-ray crystallography. Also, biological effects of these compounds on the target enzyme were evaluated by using in vitro assays, leading to the potent and selective PDE-4 inhibitor (IC50 10 nM).