121859-57-2

Basic information

• Product Name: 5,6-DICHLOROINDOLE
• Synonyms: 5,6-DICHLORO-1H-INDOLE;5,6-DICHLOROINDOLE
• CAS NO: 121859-57-2
• Molecular Formula: C₈H₅Cl₂N
• Molecular Weight: 186.04
• Product Categories: Indole/indoline/oxindole;Indole and Indoline
• Mol File: 121859-57-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 150.0 to 154.0 °C
• Boiling Point: 331.254 °C at 760 mmHg
• Flash Point: 184.263 °C
• Appearance: /
• Density: 1.479 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.695
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.19±0.30(Predicted)
• CAS DataBase Reference: 5,6-DICHLOROINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DICHLOROINDOLE(121859-57-2)
• EPA Substance Registry System: 5,6-DICHLOROINDOLE(121859-57-2)

Safety Data

• Hazardous Substances Data: 121859-57-2(Hazardous Substances Data)

Usage

General Description

5,6-Dichloroindole is a chemical compound belonging to the class of organic substances known as indoles, classified specifically under halogenated indoles. Its name indicates the presence of two chlorine atoms that are attached to its indole ring structure at the 5 and 6 positions. This chemical is known for the wide use in pharmaceutical and chemical research because the indole structure is a component of many natural and synthetic products, including some medicines. More research is needed to determine the specific properties and possible biological activities of 5,6-dichloroindole. Due to its toxicity, it needs to be handled with caution.

InChI:InChI=1/C8H5Cl2N/c9-6-3-5-1-2-11-8(5)4-7(6)10/h1-4,11H

Upstream product

• 7494-45-3 1,2-dichloro-4-methyl-5-nitrobenzene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 6374-92-1 5,7-dichloroisatin 
• 95-75-0 3,4-Dichlorotoluene 
• 229481-09-8 (E)-2-(4,5-dichloro-2-nitrophenyl)-N,N-dimethylethenamine 

Downstream Products

• 1266605-89-3 (2R,3R)-2-(2,4-difluorophenyl)-3-[4-(5,6-dichloro-1H-indol-3-ylmethyl)-piperazin-1-yl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 98640-00-7 2-(5,6-dichloro-1H-indol-3-yl)acetic acid 
• 1404532-74-6 {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5,6-dichloro-indol-1-yl}acetic acid methyl ester 
• 1404533-09-0 sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5,6-dichloro-indol-1-yl}acetate 
• 1404535-81-4 C₃₀H₃₂Cl₂N₆O₃*ClH 
• 1209183-93-6 tert-butyl 5,6-dichloro-1H-indole-1-carboxylate 
• 1677-48-1 5,6-dichloroisatin 

Relevant articles and documents

METHODS USING HDAC11 INHIBITORS

The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases.

Novel and selective 5-HT(2C/2B) receptor antagonists as potential anxiolytic agents: Synthesis, quantitative structure - Activity relationships, and molecular modeling of substituted 1-(3- pyridylcarbamoyl)indolines

The synthesis, biological activity, and molecular modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are isosteres of the previously published indole urea 1 (SB- 206553) and illustrate the use of aromatic disubstitution as a replacement for fused five-membered rings in the context of 5-HT(2C/2B) receptor antagonists. By targeting a region of space previously identified as sterically allowed at the 5-HT(2C) receptor but disallowed at the 5-HT(2A) receptor, we have identified a number of compounds which are the most potent and selective 5-HT(2C/2B) receptor antagonists yet reported. 46 (SB-221284) was selected on the basis of its overall biological profile for further evaluation as a novel, potential nonsedating anxiolytic agent. A CoMFA analysis of these compounds produced a model with good predictive value and in addition good qualitative agreement with both our 5-HT(2C) receptor model and our proposed binding mode for this class of ligands within that model.