122132-01-8

Basic information

• Product Name: 3-cyclohexyl-2-nitro-thiophene
• Synonyms: 3-cyclohexyl-2-nitro-thiophene
• CAS NO: 122132-01-8
• Molecular Weight: 211.285
• Mol File: 122132-01-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-cyclohexyl-2-nitro-thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclohexyl-2-nitro-thiophene(122132-01-8)
• EPA Substance Registry System: 3-cyclohexyl-2-nitro-thiophene(122132-01-8)

Safety Data

• Hazardous Substances Data: 122132-01-8(Hazardous Substances Data)

Upstream product

• 609-40-5 2-nitrothiophene 
• 931-50-0 cyclohexylmagnesium bromide 

Relevant articles and documents

ALKYLATION ORIENTATION RULES IN CONJUGATE ADDITION OF GRIGNARD REAGENTS TO NITROPYRROLE AND NITROTHIOPHENE SYSTEMS

Conjugate addition of various Grignard reagents to 1-alkyl-2-nitropyrroles and to 2-nitrothiophene has been investigated. 1-Alkyl-2-nitropyrroles undergo alkylation at 3 and 5 positions with prevalence of the latter isomer.On the contrary, in the 2-nitrothiophene system, formation of the 3-isomer prevails.In both systems, a bulkier Grignard reagent favours the 5-isomer formation.This trend can be reversed increasing steric hindrance exerted by the 1-substituent of 2-nitropyrrole. 1-(Tri-isopropylsilyl)-3-nitropyrrole and 3-nitrothiophene give exclusively the 2-isomer.This reaction allows 2-alkyl-3-nitrothiophenes and pyrroles to be synthesized with a one-pot procedure instead of the classical multi stage reaction.