1222-05-5Relevant articles and documents
Preparation method of galaxolide
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Paragraph 0010; 0037-0059, (2021/08/11)
The invention discloses a preparation method of galaxolide, which comprises the following steps: under the action of a supported cerium catalyst, carrying out alkylation reaction on 1, 1, 2, 3, 3, 5-hexamethylindane and epoxypropane, then carrying out dehydration condensation cyclization to generate galaxolide, and carrying out continuous rectification to separate the product. The problems of complex process, low raw material utilization rate, low safety and the like in the prior art are solved, the process is simple, the raw material conversion rate is greater than 95%, and the product selectivity is greater than 92%.
Micro-continuous flow technology for producing tonalide
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Paragraph 0023-0036, (2020/04/17)
The invention discloses a micro-continuous flow technology for producing tonalide. The technology taking 1,1,3,4,4,6-hexamethyltetrahydronaphthalene (HMT) and acetyl chloride as raw materials, anhydrous aluminum chloride as a catalyst and dichloroethane and other organic matters as a solvent comprises the following steps: mixing the anhydrous aluminum chloride, the solvent and acetyl chloride under a low-temperature condition to obtain a catalyst phase; mixing and dissolving the raw material HMT with the solvent to obtain a raw material phase; respectively pre-cooling the raw material phase and the catalyst phase, and introducing the pre-cooled raw material phase and catalyst phase into a micro-channel reactor, and performing a reaction; and finally, introducing the obtained reaction product into a microstructure mixing module, quenching and layering the obtained reaction product, and then carrying out extraction, rotary evaporation, recrystallization and drying to obtain the tonalide.The micro-continuous flow technology has the advantages of short retention time, continuousness in operation, increase of the production efficiency of the product, improvement of the production safety and the product yield by timely removing heat in the reaction process, and reduction of the risk of the quenching process by timely removing heat in the quenching process.
Synthetic process of galaxolide
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Paragraph 0037; 0040-0041; 0042; 0045-0046; 0050-0051, (2018/07/30)
The invention relates to a synthetic process of galaxolide. When an intermediate 1,1,2,3,3-pentamethylindane is prepared, macroporous strong-acidic styrenes cation exchanging resin prepared by the process is selected as a catalyst to react under a condition of no solvent, so that the pollution of waste gas, waste solids and waste water can be reduced, the solid catalysis is easy to separate, the industrialized production is facilitated, and the yield reaches up to 70 percent or more.