1222878-32-1Relevant articles and documents
Discovery and optimization of a novel, selective and brain penetrant M 1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe
Reid, Paul R.,Bridges, Thomas M.,Sheffler, Douglas J.,Cho, Hyekyung P.,Lewis, L. Michelle,Days, Emily,Daniels, J. Scott,Jones, Carrie K.,Niswender, Colleen M.,Weaver, C. David,Conn, P. Jeffrey,Lindsley, Craig W.,Wood, Michael R.
, p. 2697 - 2701 (2011/06/20)
This Letter describes a chemical lead optimization campaign directed at VU0108370, a weak M1 PAM hit with a novel chemical scaffold from a functional HTS screen within the MLPCN. An iterative parallel synthesis approach rapidly established SAR