122296-00-8 Usage
Description
1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE&, also known as 1-[(Trimethylsilyl)methyl]-1H-benzotriazole, is an organic compound that serves as a versatile reagent in various chemical reactions. It is characterized by its ability to act as a one-carbon synthon, enabling the one-carbon homologation of carboxylic acids, and its involvement in the synthesis of fused heterocycles. 1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE& is also used in alkylation reactions and as a reactant for the preparation of inhibitors of p53-MDM2 complex formation. Its physical properties include a melting point of 55-56 °C.
Uses
Used in Organic Synthesis:
1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE& is used as a reagent in the preparation of ketones and carboxylic acids, playing a crucial role in advancing the field of organic synthesis.
Used in One-Carbon Homologation of Carboxylic Acids:
In the chemical industry, 1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE& is utilized as a one-carbon synthon for the one-carbon homologation of carboxylic acids, which is an essential process in the synthesis of various organic compounds.
Used in Synthesis of Fused Heterocycles:
1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE& is also employed in the synthesis of fused heterocycles, which are important in the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Alkylation Reactions:
1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE& is used as a reactant in alkylation reactions, which are fundamental processes in organic chemistry for the formation of new chemical bonds and the creation of more complex molecules.
Used in Preparation of p53-MDM2 Complex Formation Inhibitors:
In the pharmaceutical industry, this compound serves as a reactant for the preparation of inhibitors of p53-MDM2 complex formation, which have potential applications in cancer research and therapeutics.
Used in Research and Development:
1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE& is also used in research and development settings to explore new benzotriazole reagents and their applications in various chemical processes.
Preparation
1-[(trimethylsilyl)methyl]-1H-benzotriazole
is readily prepared in a reaction of sodium benzotriazolide
with chloromethyltrimethylsilane.
Check Digit Verification of cas no
The CAS Registry Mumber 122296-00-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,2,9 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 122296-00:
(8*1)+(7*2)+(6*2)+(5*2)+(4*9)+(3*6)+(2*0)+(1*0)=98
98 % 10 = 8
So 122296-00-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N3Si/c1-14(2,3)8-13-10-7-5-4-6-9(10)11-12-13/h4-7H,8H2,1-3H3
122296-00-8Relevant articles and documents
Synthesis and structure of 1- and 2-isomers of (trimethoxysilylmethyl)- and (silatranylmethyl)benzotriazole
Voronkov,Trofimova,Bolgova,Klyba,Larina,Albanov,Pestunovich,Chernov,Petrushenko
, p. 1639 - 1644 (2003)
We have synthesized 1- and 2-(trimethylsilylmethyl)- and 1- and 2-(trimethoxysilylmethyl)benzotriazoles by reaction of 1,2,3- benzotriazolylsodium with trimethyl- or trimethoxy(chloromethyl)silane. We obtained 1- and 2-(silatranylmethyl)benzotriazoles by
Exploration of the SAR of anti-invasive chalcones: Synthesis and biological evaluation of conformationally restricted analogues
Roman, Bart I.,Ryck, Tine De,Dierickx, Laura,Vanhoecke, Barbara W.A.,Katritzky, Alan R.,Bracke, Marc,Stevens, Christian V.
experimental part, p. 4812 - 4819 (2012/09/08)
In order to get a clearer view on the active geometry of anti-invasive chalcones, we have prepared a number of isoxazoles and related substances as conformationally restrained mimics of 1,3-diarylpropenones, and also of (Z)-stilbenes. In vitro anti-invasi
Benzotriazoles. Part 15. The preparation of 1-(1-alkenyl)benzotriazoles
Katritzky, Alan R.,Offerman, Rick J.,Cabildo, Pilar,Soleiman, Mohammed
, p. 641 - 646 (2007/10/02)
The title compounds are prepared either (A) from 1-(1-chloroalkyl)benzotriazoles and aldehydes via Wittig reaction or (B) from 1-benzotriazoles by alkylative desilylation by fluoride ion in the presence of a carbonyl compound