122365-23-5

Basic information

• Product Name: N-[(diphenylphosphinoyl)methyl]-N-methylamine
• Synonyms: N-[(diphenylphosphinoyl)methyl]-N-methylamine
• CAS NO: 122365-23-5
• Molecular Weight: 245.261
• Mol File: 122365-23-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[(diphenylphosphinoyl)methyl]-N-methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(diphenylphosphinoyl)methyl]-N-methylamine(122365-23-5)
• EPA Substance Registry System: N-[(diphenylphosphinoyl)methyl]-N-methylamine(122365-23-5)

Safety Data

• Hazardous Substances Data: 122365-23-5(Hazardous Substances Data)

Upstream product

• 591-51-5 phenyllithium 
• 13119-20-5 <(dimethylamino)methyl>diphenylphosphine oxide 
• 719-80-2 Ethyl diphenylphosphinite 
• 122365-29-1 Diphenyl-(N-methyl-formamidomethyl)-phosphinoxid 

Downstream Products

• 175857-56-4 N-diphenylphosphinoylmethyl-N-methyl-2-(2-furoyl)benzamide 
• 195005-08-4 2-Bromo-N-(diphenyl-phosphinoylmethyl)-N-methyl-5-propoxy-benzamide 
• 451478-52-7 N-(tert-butoxycarbonyl)-N-[(diphenylphosphinoyl)methyl]-N-methylamine 
• 200411-10-5 3-diphenylphosphinoyl-2-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1-one 
• 724433-55-0 N-diphenylphosphinoylmethyl-2,3-dimethoxy-N-methylbenzamide 
• 380227-43-0 3-chloro-N-(diphenylphosphinoylmethyl)-N-methylisonicotinamide 
• 286434-68-2 4-benzyloxy-2-chloro-N-(diphenyl-phosphinoylmethyl)-N-methyl-benzamide 
• 286434-65-9 N-(diphenyl-phosphinoylmethyl)-6-fluoro-2,3-dimethoxy-N-methyl-benzamide 
• 286434-72-8 N-(diphenyl-phosphinoylmethyl)-2-fluoro-5,N-dimethyl-benzamide 
• 286434-70-6 N-(diphenyl-phosphinoylmethyl)-2-fluoro-4,6-dimethoxy-N-methyl-benzamide 
• 286434-63-7 N-(diphenyl-phosphinoylmethyl)-2-fluoro-6-methoxy-N-methyl-benzamide 
• 229017-34-9 N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-5-benzyloxybenzamide 
• 229017-35-0 N-Diphenylphosphinoylmethyl-N-methyl-2-(4-benzyloxybenzoyl)-4-methoxy-3-benzyloxybenzamide 
• 144175-21-3 N-(diphenyloxophosphinyl)methyl-N-methyl-2-bromobenzamide 

Relevant articles and documents

A new synthetic route to 2-alkyl-4-aryl-1(2H)-isoquinolones and 2-alkyl-4-aryl-1,2,3,4-tetrahydroisoquinolines

4-Aryl and heteroaryl-1(2H)-isoquinolones have been prepared by base promoted cyclization of phosphorylated o-aroyl and heteroaroyl benzamides. Subsequent reduction of the carbonyl and styryl functions of the annulated products has given rise to 4-aryl-1,2,3,4-tetrahydroisoquinolines.

Acylaminomethyl-diphenylphosphine Oxides

Aminomethyl-diphenylphosphine oxides 3 - 7 react with mercury(II)-edta yielding the acylamino derivatives 8 - 11.The attack at a N-methyl group and the formation of the formamide 11 in high yield is surprising, the preferred rotamer of 11 is determined.