122488-73-7

Basic information

• Product Name: 1-(bromomethyl)-4-chloro-2-methylbenzene
• Synonyms: 1-(bromomethyl)-4-chloro-2-methylbenzene
• CAS NO: 122488-73-7
• Molecular Weight: 219.509
• Mol File: 122488-73-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(bromomethyl)-4-chloro-2-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(bromomethyl)-4-chloro-2-methylbenzene(122488-73-7)
• EPA Substance Registry System: 1-(bromomethyl)-4-chloro-2-methylbenzene(122488-73-7)

Safety Data

• Hazardous Substances Data: 122488-73-7(Hazardous Substances Data)

Usage

Description

1-(bromomethyl)-4-chloro-2-methylbenzene is a chemical compound with the molecular formula C8H8BrCl. It is a derivative of benzene, featuring a bromine atom attached to a methyl group, along with a chlorine atom and another methyl group attached to the benzene ring. 1-(bromomethyl)-4-chloro-2-methylbenzene serves as a versatile building block in organic synthesis and holds potential applications across various industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
1-(bromomethyl)-4-chloro-2-methylbenzene is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be modified and functionalized to create a range of medicinally relevant compounds. Its structural diversity allows for the development of new drugs with specific therapeutic targets.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(bromomethyl)-4-chloro-2-methylbenzene is used as a precursor for the development of novel pesticides and herbicides. Its chemical structure can be tailored to target specific pests or weeds, enhancing the effectiveness and selectivity of these chemicals in agricultural applications.
Used in Materials Science:
1-(bromomethyl)-4-chloro-2-methylbenzene is utilized as a component in the creation of advanced materials, such as polymers and resins, due to its potential to influence the properties of these materials. Its incorporation can lead to improved characteristics like durability, heat resistance, or chemical stability.
It is crucial to handle 1-(bromomethyl)-4-chloro-2-methylbenzene with care, as it may pose hazards if not properly managed and stored, highlighting the importance of safety measures in its application and use.

Upstream product

• 615-60-1 4-chloro-1,2-dimethylbenzene 
• 129716-11-6 2-methyl-4-chlorobenzyl alcohol 
• 7499-07-2 4-chloro-2-methylbenzoic acid 

Downstream Products

• 947615-09-0 2-(benzhydrylidene-amino)-3-(4-chloro-2-methyl-phenyl)-propionic acid ethyl ester 
• 1610371-76-0 methyl 2-((4S,5S)-1-(4-(4-chloro-2-methylbenzyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate 

Relevant articles and documents

AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

SELECTIVITY AND MECHANISM IN THE SIDE-CHAIN HALOGENATION OF METHYLBENZENES PROMOTED PHOTOCHEMICALLY AND BY METAL COMPLEXES IN THE PRESENCE OF HALIDE IONS

The intramolecular selectivity in a variety of side-chain halogenations of alkyl-aromatics has been determined in AcOH by measuring the isomeric distribution in the reactions of 4-t-butyl- and 4-chloro-1,2-dimethylbenzene (1 and 2, respectively) with: Br2/hν, CAN/Br-, CAN=cerium(IV) ammonium nitrate, cobalt(III) acetate/Br-, S2O8=/Br-, N-bromosuccinimide (in CCl4), Cl2/hν, CAN/Cl-, cobalt(III) acetate/Cl-.In the bromination reactions selectivity is independent of the reaction conditions, thus suggesting that in all brominating systems Br. is the actual reacting species.Very surprisingly, with 1 as the substrate, Cl2/hν is a more selective system than Br2/hν.With 2 the two systems display similar selectivity.It has been suggested that in AcOH the transition state for photochlorination has an electron transfer character which increases as the substrate becomes more electron rich.The idea of a "variable" transition state for the photochlorination in AcOH is supported by data of relative reactivity of substituted toluenes indicating that the effect on the rate increases as the substituent becomes more electron donor.AcOH must have an essential role in this respect since in CCl4 situation returns to be "normal" with chlorination less selective than bromination.Selectivity of CAN/Cl- is very similar to that of Cl2/hν, whereas significant differences are observed with cobalt(III) acetate/Cl-.Probably Cl. and a cobalt(III) chloride complex are the reacting species in CAN/Cl- and cobalt(III) acetate/Cl-, respectively.