122509-74-4

Basic information

• Product Name: 6-CHLORO-5-IODOINDOLE
• Synonyms: 6-CHLORO-5-IODOINDOLE
• CAS NO: 122509-74-4
• Molecular Formula: C8H5ClIN
• Molecular Weight: 277.48947
• Mol File: 122509-74-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-CHLORO-5-IODOINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-5-IODOINDOLE(122509-74-4)
• EPA Substance Registry System: 6-CHLORO-5-IODOINDOLE(122509-74-4)

Safety Data

• Hazardous Substances Data: 122509-74-4(Hazardous Substances Data)

Usage

General Description

6-Chloro-5-iodoindole is a chemical compound that belongs to the class of indole derivatives. It is a derivative of the heterocyclic compound indole, which is commonly found in various natural products and pharmaceuticals. 6-Chloro-5-iodoindole is an aromatic compound with chlorine and iodine atoms attached to the indole ring. It is used as a building block in the synthesis of various organic molecules, particularly in the field of medicinal chemistry and drug discovery. The compound has potential applications in the development of new pharmaceuticals and agrochemicals due to its unique properties and reactivity.

Upstream product

• 135050-44-1 3-chloro-4-iodoaniline 
• 143937-73-9 N-(3-chloro-4-iodophenyl)methanesulfonamide 

Relevant articles and documents

Novel and selective 5-HT(2C/2B) receptor antagonists as potential anxiolytic agents: Synthesis, quantitative structure - Activity relationships, and molecular modeling of substituted 1-(3- pyridylcarbamoyl)indolines

The synthesis, biological activity, and molecular modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are isosteres of the previously published indole urea 1 (SB- 206553) and illustrate the use of aromatic disubstitution as a replacement for fused five-membered rings in the context of 5-HT(2C/2B) receptor antagonists. By targeting a region of space previously identified as sterically allowed at the 5-HT(2C) receptor but disallowed at the 5-HT(2A) receptor, we have identified a number of compounds which are the most potent and selective 5-HT(2C/2B) receptor antagonists yet reported. 46 (SB-221284) was selected on the basis of its overall biological profile for further evaluation as a novel, potential nonsedating anxiolytic agent. A CoMFA analysis of these compounds produced a model with good predictive value and in addition good qualitative agreement with both our 5-HT(2C) receptor model and our proposed binding mode for this class of ligands within that model.