1225199-26-7

Basic information

• Product Name: Urea, N-[(3-Methoxyphenyl)Methyl]-N-Methyl-N'-[4-(1H-pyrazol-4-yl)-2-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
• Synonyms: Urea, N-[(3-Methoxyphenyl)Methyl]-N-Methyl-N'-[4-(1H-pyrazol-4-yl)-2-[2-(1-pyrrolidinyl)ethoxy]phenyl]-;1-(3-Methoxy-benzyl)-1-Methyl-3-[4-(1H-pyrazol-4-yl)-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-urea;1-[(3-methoxyphenyl)methyl]-1-methyl-3-[4-(1H-pyrazol-4-yl)-2-(2-pyrrolidin-1-ylethoxy)phenyl]urea
• CAS NO: 1225199-26-7
• Molecular Formula: C₂₅H₃₁N₅O₃
• Molecular Weight: 449.54534
• Mol File: 1225199-26-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Urea, N-[(3-Methoxyphenyl)Methyl]-N-Methyl-N'-[4-(1H-pyrazol-4-yl)-2-[2-(1-pyrrolidinyl)ethoxy]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-[(3-Methoxyphenyl)Methyl]-N-Methyl-N'-[4-(1H-pyrazol-4-yl)-2-[2-(1-pyrrolidinyl)ethoxy]phenyl]-(1225199-26-7)
• EPA Substance Registry System: Urea, N-[(3-Methoxyphenyl)Methyl]-N-Methyl-N'-[4-(1H-pyrazol-4-yl)-2-[2-(1-pyrrolidinyl)ethoxy]phenyl]-(1225199-26-7)

Safety Data

• Hazardous Substances Data: 1225199-26-7(Hazardous Substances Data)

Upstream product

• 269410-08-4 pyrazole-4-boronic acid pinacol ester 

Relevant articles and documents

Discovery of potent and selective urea-based ROCK inhibitors and their effects on intraocular pressure in rats

A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate DMPK profiles for topical applications as antiglaucoma therapeutics.