122520-12-1

Basic information

• Product Name: 7-Nitro-2-tetralone
• Synonyms: 7-Nitro-2-tetralone;7-Nitro-3,4-dihydro-1H-naphthalen-2-one;4-dihydro-7-nitro-;7-Nitro-3,4-dihydronaphthalen-2(1H)-one
• CAS NO: 122520-12-1
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191.18
• Mol File: 122520-12-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 105 °C(Solv: ethanol (64-17-5))
• Boiling Point: 357°C at 760 mmHg
• Flash Point: 180.7°C
• Appearance: /
• Density: 1.322g/cm³
• Vapor Pressure: 2.82E-05mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: 7-Nitro-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Nitro-2-tetralone(122520-12-1)
• EPA Substance Registry System: 7-Nitro-2-tetralone(122520-12-1)

Safety Data

• Hazardous Substances Data: 122520-12-1(Hazardous Substances Data)

Usage

General Description

7-Nitro-2-tetralone is a chemical compound with the molecular formula C11H9NO3. It is a nitroaromatic compound that is commonly used in the synthesis of various pharmaceuticals and organic compounds. This yellow crystalline solid is primarily used as a building block in organic synthesis and as a precursor to a variety of chemical products. It is also known for its potential use in the development of new drugs, as its molecular structure makes it a valuable starting material for the creation of novel pharmaceuticals. Additionally, 7-Nitro-2-tetralone has been studied for its potential as a fluorescent probe for detecting biological molecules and as a photoinitiator in photopolymerization processes.

InChI:InChI=1/C10H9NO3/c12-10-4-2-7-1-3-9(11(13)14)5-8(7)6-10/h1,3,5H,2,4,6H2

Upstream product

• 122520-11-0 1,2-epoxy-7-nitro-1,2,3,4-tetrahydronaphthalene 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 40353-34-2 7-nitro-3,4-dihydro-2H-naphthalen-1-one 
• 32820-11-4 7-nitro-1,2,3,4-tetrahydronaphthalen-1-ol 
• 122520-10-9 7-nitro-3,4-dihydronaphthalene 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Downstream Products

• 87732-56-7 (S)-1-(3,4-Dihydro-7-nitro-2-naphthyl)-2-(methoxymethyl)pyrrolidin 
• 101167-13-9 7-nitro-1,2,3,4-tetrahydro-[2]naphthylamine 
• 204843-01-6 1-(2'-Nitro-4',5'-dimethoxybenzylidene)-7-nitro-2-tetralone 
• 1003565-41-0 7-nitro-N-[2-(4-phenylpiperazin-1-yl)ethyl]-1,2,3,4-tetrahydronaphthalen-2-amine 

Relevant articles and documents

Transition state imbalance in proton transfer from phenyl ring-substituted 2-tetralones to acetate ion

Rate constants for the acetate ion-catalyzed ketonization of phenyl-substituted 2-tetralone enols have been determined by stopped-flow UV spectroscopy. From these rate constants and the keto - enol equilibrium constants, the rate constants (k-2) for enolization were calculated. A Bronsted plot of these rate constants (log k-2) vs the acidity of the appropriate 2-tetralone (pKaK) is linear, with a slope ( - αE) of - 0.78 ± 0.03, except for the point corresponding to 6-nitro-2-tetralone (4b). Rate constants for the ionization of 2-tetralone by substituted acetates were determined directly by NMR, giving a corresponding Bronsted βE of 0.54 ± 0.03. Both the negative deviation of the point for 4b from the correlation line for αE and the inequality between αE and βE indicate an imbalanced transition state for the proton abstraction of 2-tetralone by acetate ion. This reaction is impeded by a thermodynamic barrier of 11 kcal/mol, along with an intrinsic kinetic barrier of 14 kcal/mol. A comparison of the transition states for proton abstraction of 2-tetralone by hydroxide ion and by acetate ion shows similar transition state imbalance and intrinsic kinetic barriers for both reactions. The relevance of these results to the mechanism of enzymatic acceleration of enolization is discussed.

2-Pyrimidinyl Pyrazolopyridine ErbB Kinase Inhibitors

The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors

The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

Diphenylurea compounds

wherein: R1, R2, R3 and R4 independently represent hydrogen, halogen, or alkyl, alkoxy, hydroxy, cyano, optionally substituted amino, nitro, carboxy, alkoxycarbonyl, optionally substituted aminocarbonyl or carba