1225322-64-4

Basic information

• Product Name: 7-bromo-1-methyl-3-(trifluoromethyl)quinoxalin-2(1H)-one
• Synonyms: 7-bromo-1-methyl-3-(trifluoromethyl)quinoxalin-2(1H)-one
• CAS NO: 1225322-64-4
• Molecular Weight: 307.07
• Mol File: 1225322-64-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-bromo-1-methyl-3-(trifluoromethyl)quinoxalin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-bromo-1-methyl-3-(trifluoromethyl)quinoxalin-2(1H)-one(1225322-64-4)
• EPA Substance Registry System: 7-bromo-1-methyl-3-(trifluoromethyl)quinoxalin-2(1H)-one(1225322-64-4)

Safety Data

• Hazardous Substances Data: 1225322-64-4(Hazardous Substances Data)

Upstream product

• 2926-29-6 Langlois reagent 
• 82019-32-7 1-methyl-7-bromoquinoxaline-2(1H)-one 

Relevant articles and documents

Direct C?H Trifluoromethylation of Quinoxalin-2(1H)-ones under Transition-Metal-Free Conditions

Disclosed herein is a direct C?H trifluoromethylation of quinoxalin-2(1H)-ones with sodium trifluoromethanesulfinate. This protocol affords a series of 3-trifluoromethylquinoxalin-2(1H)-one derivatives in moderate to excellent yields under transition-metal-free conditions. The present methodology features utilization of the inexpensive trifluoromethyl source without transition-metal-catalysts, mild reaction conditions and high functional group tolerance, which promises a convenient and efficient access to pharmaceutically interesting quinoxalinones. (Figure presented.).