1225919-63-0

Basic information

• Product Name: 4-(3-methylbenzyl)piperidin-4-ol
• CAS NO: 1225919-63-0
• Molecular Weight: 205.3
• Mol File: 1225919-63-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(3-methylbenzyl)piperidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-methylbenzyl)piperidin-4-ol(1225919-63-0)
• EPA Substance Registry System: 4-(3-methylbenzyl)piperidin-4-ol(1225919-63-0)

Safety Data

• Hazardous Substances Data: 1225919-63-0(Hazardous Substances Data)

Upstream product

• 29875-06-7 3-methylbenzylmagnesium chloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Relevant articles and documents

Synthesis and SAR of thieno[3,2-b]pyridinyl urea derivatives as urotensin-II receptor antagonists

The preparation and SAR profile of thieno[3,2-b]pyridinyl urea derivatives as novel and potent urotensin-II receptor antagonists are described. An activity optimization study, probing the effects of substituents on thieno[3,2-b]pyridinyl core and benzyl group of the piperidinyl moiety, led to the identification of p-fluorobenzyl substituted thieno[3,2-b]pyridinyl urea 6n as a highly potent UT antagonist with an IC50 value of 13 nM. Although 6n displays good metabolic stability and low hERG binding activity, it has an unacceptable oral bioavailability.