1227000-48-7

Basic information

• Product Name: (E)-3-styrylquinolin-4(1H)-one
• Synonyms: (E)-3-styrylquinolin-4(1H)-one
• CAS NO: 1227000-48-7
• Molecular Weight: 247.296
• Mol File: 1227000-48-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-3-styrylquinolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-styrylquinolin-4(1H)-one(1227000-48-7)
• EPA Substance Registry System: (E)-3-styrylquinolin-4(1H)-one(1227000-48-7)

Safety Data

• Hazardous Substances Data: 1227000-48-7(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 1257983-13-3 (E)-4-chloro-3-styrylquinoline 
• 1257983-09-7 (Z)-4-chloro-3-styrylquinoline 

Downstream Products

• 1227000-53-4 (E)-1-methyl-3-(2-phenylvinyl)quinolin-4(1H)-one 
• 1316830-68-8 (Z)-3-styrylquinolin-4(1H)-one 

Relevant articles and documents

Synthesis of (2-Aminophenyl)(naphthalen-2-yl)methanones via Intramolecular Rearrangement of (E)-3-Styrylquinolin-4(1 H)-ones under Irradiation with 365 nm UV Light

A highly efficient and environmentally friendly synthesis of (2-aminophenyl)(naphthalen-2-yl)methanones was developed. The (2-aminophenyl)(naphthalen-2-yl)methanone derivatives were obtained in high yields (up to 96%) by the irradiation of (E)-3-styrylquinolin-4(1 H)-ones in EtOH-H 2 O (7:1) with UV light (365 nm) at room temperature under Ar atmosphere. The demonstrated photoinduced intramolecular rearrangement has advantages over other transition-metal-catalyzed reactions, e.g. no requirement of additives, green solvent, broad substrate scope, and high atom efficiency.

Reactivity of 3-iodo-4-quinolones in heck reactions: Synthesis of novel (E)-3-styryl-4-quinolones

A new and efficient route for the synthesis of (E)-N-?methyl-3-styryl-4- quinolones is described. It involves the Heck ?reaction of N-methyl-3-iodo-4- quinolone, which is obtained by consecutive 3-iodination and NH-methylation of the unsubstituted 4-quinolone, with styrene derivatives. It is demonstrated that such a procedure is only efficient when the 3-iodo-4-quinolone has an N-protecting group. In some cases the branched regioisomers N-methyl-3-(1- phenylethenyl)-4-quinolones were also obtained as byproducts. Georg Thieme Verlag Stuttgart · New York.