1227294-01-0Relevant articles and documents
A scalable synthesis of (±)-2-oxoclopidogrel
Velder, Janna,Hirschh?user, Christoph,Waldmann, Christopher,Taubert, Dirk,Bouman, Heleen J.,Schmalz, Hans-Günther
scheme or table, p. 467 - 469 (2010/06/13)
As a precondition for detailed pharmacological investigations, an efficient chemical method for the conversion of the antiplatelet drug clopidogrel into its first metabolite 2-oxoclopidogrel was developed. The one-pot procedure, which can easily be performed on a gram scale, exploits the selective borylation of a di-anionic intermediate derived from clopidogrel with subsequent oxidative workup.