1228029-77-3Relevant articles and documents
Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain
Beebe, Xenia,Yeung, Clinton M.,Darczak, Daria,Shekhar, Shashank,Vortherms, Timothy A.,Miller, Loan,Milicic, Ivan,Swensen, Andrew M.,Zhu, Chang Z.,Banfor, Patricia,Wetter, Jill M.,Marsh, Kennan C.,Jarvis, Michael F.,Scott, Victoria E.,Schrimpf, Michael R.,Lee, Chih-Hung
, p. 4857 - 4861 (2013/09/02)
A novel series of N-type calcium channel inhibitors have been discovered. Optimization of potency and HT-ADME properties provides 4- aminocyclopentapyrrolidines with analgesic efficacy after oral dosing.
N-ALKYL-AZACYCLOALKYL NMDA/NR2B ANTAGONISTS
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Page/Page column 28; 69, (2008/06/13)
Compounds represented by Formula (I): and/or pharmaceutically acceptable salts, individual enantiomers and stereoisomers thereof, are effective as NMDA/NR2B antagonists useful for treating conditions such as pain, Parkinson’s disease, Alzheimer’s disease, epilepsy, depression, anxiety, ischemic brain injury including stroke.