123-03-5 Usage
Description
Cetylpyridinium chloride (CPC) is a quaternary ammonium compound with broad-spectrum antiseptic properties. It is a white powder or crystals with a characteristic odor and is slightly soapy to the touch. CPC is active against various bacteria and fungi, making it a versatile agent for treating minor infections of the mouth and throat.
Uses
Used in Oral Care Products:
Cetylpyridinium chloride is used as an antiseptic and antimicrobial agent in mouthwashes and lozenges for the treatment of minor infections of the mouth and throat. It is effective against bacteria such as S. mutans, S. sanguis, E. coli, Oxford Staphylococcus, and C. albicans, as well as inhibiting plaque formation for at least 21 days when applied topically at concentrations ranging from 0.025 to 2%.
Used in Pharmaceutical Industry:
Cetylpyridinium chloride is used as a preservative in the pharmaceutical industry due to its quaternary ammonium compound nature. It helps maintain the stability and safety of various products by preventing microbial contamination.
Used in Cosmetics:
In the cosmetics industry, CPC is used as a preservative to ensure the longevity and safety of products. Its antimicrobial properties help prevent the growth of harmful microorganisms that could cause infections or spoilage.
Used in Raw Food Processing:
Cetylpyridinium chloride is used as an antimicrobial agent in raw food processing to maintain the quality and safety of the products. It helps prevent the growth of harmful bacteria and extends the shelf life of the food items.
Used in Cough Lozenges and Syrups:
Cetylpyridinium chloride is used as an antibacterial agent in cough lozenges and syrups to help treat respiratory infections and soothe throat irritation.
Used as an Emulsifier:
CPC is also utilized as an emulsifier in various industries, including pharmaceuticals and cosmetics, to help blend and stabilize mixtures of oil and water.
Used on the Surface of Latex Gloves:
Cetylpyridinium chloride is used as a topical anti-infective and disinfectant on the surface of latex gloves, providing an additional layer of protection against the transmission of infections.
Brand Names:
Some well-known brand names for products containing cetylpyridinium chloride include Ceepryn (Marion Merrell Dow) and Cepacol (Marion Merrell Dow).
Production Methods
Cetylpyridinium chloride is prepared from cetyl chloride by
treatment with pyridine.
Flammability and Explosibility
Nonflammable
Pharmaceutical Applications
Cetylpyridinium chloride is a quaternary ammonium cationic
surfactant, used in pharmaceutical and cosmetic formulations as
an antimicrobial preservative. It is used therapeutically
as an antiseptic agent; used alone or in combination with
other drugs for oral and throat care; used in nonparenteral
formulations licensed in the UK; and used in oral and inhalation
preparations at concentrations of 0.02–1.5 mg.
Mouthwashes containing cetylpyridinium chloride have been
shown to inhibit plaque formation,(1–3) although efficacy is variable
owing to limited published data.
Clinical Use
1-Hexadecylpyridinium chloride is a white powder that isvery soluble in water and alcohol. In this compound, thequaternary nitrogen atom is a member of an aromatic pyridinering.The cetyl derivative is the most active of a series ofalkylpyridinium compounds. It is used as a general antisepticin concentrations of 1:100 to 1:1,000 for intact skin,1:1,000 for minor lacerations, and 1:2,000 to 1:10,000 forthe irrigation of mucous membranes. Cetylpyridinium chlorideis also available in the form of throat lozenges and amouthwash at a 1:20,000 dilution.
Safety Profile
Poison by ingestion,
intraperitoneal, subcutaneous, and
intravenous routes. Moderately toxic by skin
contact. A skin and eye irritant. When
E heated to decomposiuon it emits very toxic
fumes of NOx and Cl-.
Safety
Cetylpyridinium chloride is used widely in mouthwashes as a
bactericidal antiseptic. It is generally regarded as a relatively
nontoxic material when used at a concentration of 0.05% w/v,
although minor side effects such as mild burning sensations on the
tongue have been reported.
At higher concentrations, cetylpyridinium chloride may damage
the mucous membranes in the mouth. It is harmful when ingested or
inhaled. It can cause eye irritation, and is irritant to the respiratory
system and the skin.
LD50 (rat, IP): 0.006 g/kg
LD50 (rat, IV): 0.03 g/kg
LD50 (rat, oral): 0.2 g/kg
LD50 (rat, SC): 0.25 g/kg
LD50 (mouse, IP): 0.01 g/kg
LD50 (mouse, oral): 0.108 g/kg
LD50 (rabbit, oral): 0.4 g/kg
LD50 (rabbit, IV): 0.036 g/kg
storage
Cetylpyridinium chloride is stable under normal conditions. It
should be stored in well-closed containers.
Incompatibilities
Incompatible with strong oxidizing agents and bases. It is also
incompatible with methylcellulose.
Magnesium stearate suspensions in cetylpyridinium chloride
have been shown to significantly reduce its antimicrobial activity.
This is due to the absorption of cetylpyridinium chloride on
magnesium stearate. The cetylpyridinium chloride ion also
interacts with gelatin, resulting in reduced bioavailability.
Regulatory Status
Included in nonparenteral formulations licensed in the UK. Included
in the FDA Inactive Ingredients Database, for use in inhalation and
oral preparations. Reported in the EPA TSCA Inventory. It is not
approved for use in Japan. Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 123-03-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 123-03:
(5*1)+(4*2)+(3*3)+(2*0)+(1*3)=25
25 % 10 = 5
So 123-03-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H38N.2ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-22-20-17-15-18-21-22;;/h15,17-18,20-21H,2-14,16,19H2,1H3;2*1H/q+1;;/p-2
123-03-5Relevant articles and documents
Surfactant Aggregation Number and Polydispersity of SDS + 1-Pentanol Mixed Micelles in Brine Determined by Time-Resolved Fluorescence Quenching
Lang, Jacques
, p. 3734 - 3739 (1990)
Size and polydispersity of sodium dodecyl sulfate (SDS) + 1-pentanol direct mixed micelles have been investigated by means of the time-resolved fluorescence quenching method in the system SDS/1-pentanol/water/NaCl ( = 0.0331 M, = 0.42 M, and = 6.5 g/L of water).This method reveals high polydispersity in micellar size.Several size distribution models have been tested.The one that best fits the data is a double Gaussian distribution which suggests that two populations of mixed micelles might be present in the solution, centered on the SDS mean aggregation numbers of 75 and 830.
AN IMPROVED PROCESS FOR THE PRODUCTION OF QUATERNARY PYRIDINIUM SALTS
-
Page/Page column 8, (2016/06/28)
Disclosed herein is cost effective and eco-friendly process for producing quaternary pyridinium salts and their hydrates thereof, with high yield and purity at industrial scale.
FUNGICIDAL PENFLUFEN MIXTURES
-
, (2014/04/03)
The invention relates to mixtures comprising penflufen, to the use of these mixtures for protecting industrial materials and to a method for treating industrial materials with the penflufen mixtures.
