123054-31-9

Basic information

• Product Name: 7-PHENYLACETAMIDE-3-HYDROXY-3-CEPHEM-4-CARBOXYLIC ACID P-METHOXYBENZYL ESTER
• Synonyms: 7-PHENYLACETAMIDE-3-HYDROXY-3-CEPHEM-4-CARBOXYLIC ACID P-METHOXYBENZYL ESTER;GHYE;7-pheylacetamide-3-hydroxy-3-cephem-4-carboxylic acid- p- methoxybengyl ester
• CAS NO: 123054-31-9
• Molecular Formula: C₂₃H₂₂N₂O₆S
• Molecular Weight: 454.5
• Mol File: 123054-31-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-PHENYLACETAMIDE-3-HYDROXY-3-CEPHEM-4-CARBOXYLIC ACID P-METHOXYBENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 7-PHENYLACETAMIDE-3-HYDROXY-3-CEPHEM-4-CARBOXYLIC ACID P-METHOXYBENZYL ESTER(123054-31-9)
• EPA Substance Registry System: 7-PHENYLACETAMIDE-3-HYDROXY-3-CEPHEM-4-CARBOXYLIC ACID P-METHOXYBENZYL ESTER(123054-31-9)

Safety Data

• Hazardous Substances Data: 123054-31-9(Hazardous Substances Data)

Upstream product

• 131857-34-6 (E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-hydroxy-but-2-enoic acid 4-methoxy-benzyl ester 
• 164032-73-9 (6R,7R)-3-Benzhydryloxy-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 146340-02-5 1-<3-chloro-2-hydroxy-1-(p-methoxybenzyloxycarbonyl)-1-propen-1-yl>-3-(phenylacetamido)-4-(phenylsulfonylthio)-2-azetidinone 
• 131903-39-4 1-<2-chloromethyl-1-(p-methoxybenzyloxycarbonyl)-2-propen-1-yl>-3-(phenylacetamido)-4-(phenylsulfonylthio)-2-azetidinone 
• 164201-46-1 1-<3-chloro-1-(p-methoxybenzyloxycarbonyl)-2-(diphenylmethyloxy)-1-propen-1-yl>-3-(phenylacetamido)-4-(phenylsulfonylthio)-2-azetidinone 
• 164201-45-0 1-<3-chloro-1-(p-methoxybenzyloxycarbonyl)-2-(diphenylmethyloxy)-1-propen-1-yl>-3-(phenylacetamido)-4-(phenylsulfonylthio)-2-azetidinone 

Downstream Products

• 123054-30-8 (7R)-7-[(phenylacetyl)amino]-3-trifluoromethanesulfonyloxy-3-cephem-4-carboxylate, 4-methoxybenzyl ester 
• 342811-88-5 p-methoxybenzyl 3-(imidazo[1,2-b]pyridazine-6-yl)thio-7β-phenylacetylamino-3-cephem-4-carboxylate 

Relevant articles and documents

Synthesis of 3-hydroxycephems from penicillin G through cyclization of chlorinated 4-(phenylsulfonylthio)-2-azetidinones promoted by a BiCl3/Sn or TiCl4/Sn bimetal redox system

A novel access to 3-hydroxycephems was attained from penicillin G via the C=C bond cleavage of 1-(1-alkoxycarbonyl-2-chloromethyl-2-propenyl)-4-(phenylsulfonylthio)- 2-azetidinones by successive treatment with RuCl3/HIO4 and HIO4/CuSO4 and reductive cyclization of I-(I-alkoxycarbonyl-3-chloro-2-hydroxy-1-propenyl)-4-(phenylsulfonylth io)-2-azetidinones on treatment with a newly devised BiCl3/Sn or TiCl4/Sn bimetal redox couple in DMF containing pyridine.