123075-23-0 Usage
Description
2'-Deoxyisocytidine is a deoxyribonucleoside, which is a type of nucleoside that plays a crucial role in the structure and function of DNA. It is characterized by the presence of a deoxyribose sugar and a cytosine base. 2'-Deoxyisocytidine has gained attention for its potential applications in various fields, particularly as an L-nucleoside analog in the development of anti-viral drugs.
Uses
Used in Pharmaceutical Industry:
2'-Deoxyisocytidine is used as an L-nucleoside analog for its anti-viral properties. It serves as a key component in the development of anti-viral drugs due to its ability to inhibit viral replication and reduce the severity of viral infections. This makes it a valuable asset in the fight against various viral diseases, including those caused by RNA and DNA viruses.
Used in Research and Development:
In addition to its pharmaceutical applications, 2'-Deoxyisocytidine is also utilized in research and development for the study of DNA structure, function, and replication. Its unique properties allow scientists to investigate the mechanisms of DNA synthesis, repair, and mutation, contributing to a deeper understanding of genetic processes and the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 123075-23-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,0,7 and 5 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 123075-23:
(8*1)+(7*2)+(6*3)+(5*0)+(4*7)+(3*5)+(2*2)+(1*3)=90
90 % 10 = 0
So 123075-23-0 is a valid CAS Registry Number.
123075-23-0Relevant articles and documents
2′-Deoxyuridine and 2′-deoxyisocytidine as constituents of DNA with parallel chain orientation: The stabilization of the iCd·Gd base pair by the 5-methyl group
Seela, Frank,He, Yang
, p. 2527 - 2540 (2007/10/03)
Parallel-stranded oligonucleotides containing 2′-deoxyuridine (2) and 2′-deoxyisocytidine (4) were synthesized. The phosphoramidite 11 employed in the solid-phase synthesis carries a (dimethylamino)methylidene residue as amino-protecting group. This group stabilizes the acid-labile glycosylic bond of 4 and enables the base-catalyzed deprotection of oligonucleotides without degrading the nucleoside 4 residues. Oligonucleotide duplexes incorporating the 5-Me derivatives of 2 (→2′-deoxythymidine) and 4 (→2′-deoxy-5-methylisocytidine), which are more stable than those containing the unmethylated nucleosides, were also compared. Depending on the nearest-neighbor environment. Me groups provide an additional stabilization through Me/Me contacts or Me/backbone interactions.
