123158-78-1 Usage
Description
1-iodo-3-methyl-5-nitroBenzene is a chemical compound with the molecular formula C7H6INO2. It is a derivative of benzene, containing a nitro group (NO2) at the 5th position, a methyl group (CH3) at the 3rd position, and an iodine atom (I) at the 1st position. This yellow crystalline solid is insoluble in water but soluble in organic solvents such as ethanol and acetone. Due to its toxic nature and potential to cause skin and eye irritation, it requires careful handling.
Uses
Used in Pharmaceutical Industry:
1-iodo-3-methyl-5-nitroBenzene is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
1-iodo-3-methyl-5-nitroBenzene is used as an intermediate in the synthesis of agrochemicals to help create compounds that can be used in the development of pesticides and other agricultural products.
Used in Chemical Research:
1-iodo-3-methyl-5-nitroBenzene is used as a reagent in organic synthesis, playing a crucial role in advancing chemical research and the discovery of new chemical reactions and processes.
Used in Organic Synthesis:
1-iodo-3-methyl-5-nitroBenzene is used as a reagent in organic synthesis for its potential to form a variety of complex organic compounds, contributing to the advancement of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 123158-78-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,1,5 and 8 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 123158-78:
(8*1)+(7*2)+(6*3)+(5*1)+(4*5)+(3*8)+(2*7)+(1*8)=111
111 % 10 = 1
So 123158-78-1 is a valid CAS Registry Number.
123158-78-1Relevant articles and documents
Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group
Fu, Zhengjiang,Jiang, Yongqing,Wang, Shuiliang,Song, Yuanyuan,Guo, Shengmei,Cai, Hu
supporting information, p. 3003 - 3007 (2019/05/10)
A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.
The Kinetics of the Reactions of Picryl Chloride with Some Substituted Anilines. Part 5.
Emokpae, Thomas A.,Eguavoen, Osa,Hirst, Jack
, p. 829 - 831 (2007/10/02)
Arrhenius parameters have been measured for the reactions of picryl chloride with the following substituted anilines in acetonitrile: 3-amino- and 3-methyl-aniline, 3-amino-5-nitroaniline, 3-fluoro-5-methylsulphonylaniline, 3-X-5-methylanilines (X=NO2, OMe, CH3, F, Cl, Br, or I) and 3,5-X2-anilines (X = F, Cl, Br, or I).A total of 33 3,5-disubstituted anilines have now been examined for the additivity of substituent effects on the free energy of activation, and it has been shown that with the exception of 3-amino-5-nitroaniline this hypothesis reproduces experimental rate constants within a factor of 2.A rationalization is proposed for the deviations that occur in some cases when more stringent criteria of additivity are used.
