1232-80-0 Usage
Description
2-Hydroxyestriol is a metabolite of 17β-estradiol and estrone, which are naturally occurring estrogens in the human body. It is formed through the selective expression of 15 human cytochrome P450 isoforms, which are enzymes involved in the oxidative metabolism of these hormones.
Uses
Used in Pharmaceutical Research:
2-Hydroxyestriol is used as a biomarker for the activity of specific cytochrome P450 isoforms, which are important in the metabolism of various drugs and endogenous compounds. The presence and levels of 2-hydroxyestriol can provide valuable information on the function and regulation of these enzymes, which can be useful in the development of personalized medicine and drug therapies.
Used in Endocrinology and Hormone Research:
2-Hydroxyestriol is used as a research tool to study the metabolism and regulation of estrogens in the body. Understanding the role of 2-hydroxyestriol and its formation can help researchers gain insights into the complex hormonal balance and its impact on various physiological processes, including reproductive health, bone density, and cardiovascular function.
Used in Toxicology and Drug Interaction Studies:
2-Hydroxyestriol can be used to investigate the potential toxic effects of certain drugs or environmental chemicals on the human endocrine system. By monitoring the levels of 2-hydroxyestriol and other related metabolites, researchers can assess the impact of these substances on the normal functioning of the cytochrome P450 enzymes and the overall hormonal balance in the body.
Check Digit Verification of cas no
The CAS Registry Mumber 1232-80-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,3 and 2 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1232-80:
(6*1)+(5*2)+(4*3)+(3*2)+(2*8)+(1*0)=50
50 % 10 = 0
So 1232-80-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H24O4/c1-18-5-4-10-11(13(18)8-16(21)17(18)22)3-2-9-6-14(19)15(20)7-12(9)10/h6-7,10-11,13,16-17,19-22H,2-5,8H2,1H3/t10-,11+,13-,16+,17-,18-/m0/s1
