1232-99-1Relevant articles and documents
Zirconium(IV) chloride as versatile catalyst for the expeditious synthesis of quinoxalines and pyrido[2,3-b]pyrazines under ambient conditions
Aghapoor, Kioumars,Darabi, Hossein Reza,Mohsenzadeh, Farshid,Balavar, Yadollah,Daneshyar, Hesam
, p. 49 - 53 (2010)
Among the various transition metal chlorides, zirconium(IV) chloride was found to be an efficient catalyst for the rapid synthesis of a wide range of 2,3-dialkyl- and 2,3-diaryl-quinoxaline and pyrido[2,3-b]pyrazine derivatives in excellent yields at room temperature. The remarkable features of this catalytic process are the mild reaction conditions, quantitative yields, short reaction times, high conversions, tolerability of various functional groups, clean reaction profiles, and operational simplicity. Graphical Abstract: Among the various transition metal chlorides, zirconium(IV) chloride was found to be an efficient catalyst for the rapid synthesis of a wide range of 2,3-dialkyl- and 2,3-diaryl-quinoxaline and pyrido[2,3-b]pyrazine derivatives in excellent yields at room temperature. The remarkable features of this catalytic process are the mild reaction conditions, quantitative yields, short reaction times, high conversions, tolerability of various functional groups, clean reaction profiles, and operational simplicity.
A recyclable solid acid catalyst sulfated titania for easy synthesis of quinoxaline and dipyridophenazine derivatives under microwave irradiation
Krishnakumar, Balu,Swaminathan, Meenakshisundaram
, p. 1261 - 1266 (2011)
TiO2SO42, prepared by solgel method has been used for the synthesis of quinoxaline and dipyridophenizine derivatives under microwave irradiation. High-resolution transmission electron microscope (HR-TEM) and atomic force m
Synthesis of quinoxalines by a carbon nanotube-gold nanohybrid-catalyzed cascade reaction of vicinal diols and keto alcohols with diamines
Shah, Nimesh,Gravel, Edmond,Jawale, Dhanaji V.,Doris, Eric,Namboothiri, Irishi N. N.
, p. 57 - 61 (2015)
A one-pot oxidation-condensation method for the synthesis of quinoxalines from readily available benzoins or benzhydrols and 1,2-phenylenediamines or 2,3-diaminopyridine by use of a gold-carbon nanotube nanohybrid as a heterogeneous catalyst is reported. Quinoxalines are formed under mild conditions in air and in excellent yields. The simple and efficient methodology offers a safe and sustainable alternative to conventional acid and/or base-catalyzed thermal processes.
Sustainable approach to tandem catalysis: Expedient access to quinoxalines and pyrido[2,3-b]pyrazines from α-hydroxyketones via microwave-induced [(NH4)6Mo7O24·4H 2O - PEG 300] polar paste catalyst system
Aghapoor, Kioumars,Mohsenzadeh, Farshid,Mohebi Morad, Mina,Darabi, Hossein Reza
, p. 764 - 767 (2012)
[(NH4)6Mo7O24·4H 2O-PEG 300] is introduced as a polar paste catalyst system for tandem synthesis of quinoxalines and pyrido[2,3-b]pyrazines under open-vessel focused microwave irradiation. Low conversions were obtained when catalyst or PEG was used individually. Accordingly, a convenient combination of catalyst and PEG mostly led to quantitative yield of products within 15 min microwave irradiation with good turnover frequency values (11-20 h-1) taking a tandem process into consideration. The salient features of this environmentally benign method are fast conversions, high product selectivity and the use of a low-cost, readily available, nontoxic, catalyst and medium.
ZrOCl2.8H2O in water: An efficient catalyst for rapid one-pot synthesis of pyridopyrazines, pyrazines and 2,3-disubstituted quinoxalines
Bardajee, Ghasem Rezanejade
, p. 872 - 877 (2013)
Zirconium(IV) oxide chloride was found to be a rapid and efficient catalyst for the synthesis of pyrazines and 2,3-disubstituted quinoxalines in water. A variety of pyridopyrazine and 2,3-disubstituted quinoxaline derivatives are readily prepared in high yields under green conditions by cyclocondensation of the desired 1,2-diamine and 1,2-diketone using a catalytic amount of zirconium(IV) oxide chloride in water. Less active diamines, such as 2,3- and 3,4-diaminopyridines took part in this protocol to provide the desired products in good to excellent yields.
Pentafluorophenylammonium triflate: A highly efficient catalyst for the synthesis of quinoxaline derivatives in water
Khaksar, Samad,Radpeyma, Hanieh
, p. 1023 - 1027 (2014)
A simple, inexpensive, environmentally friendly and efficient route for the rapid and efficient synthesis of quinoxaline derivatives using pentafluorophenylammonium triflate (PFPAT) as a catalyst is described. Various quinoxaline derivatives were synthesi
Zirconium schiff-base complex modified mesoporous silica as an efficient catalyst for the synthesis of nitrogen containing pyrazine based heterocycles
Malakooti, Reihaneh,Bardajee, Ghasem Rezanejade,Mahmoudi, Hesamaldin,Kakavand, Nahale
, p. 853 - 861 (2013)
Zirconium Schiff-base complex modified SBA-15 was synthesized and characterized by powder X-ray diffraction (XRD), BET nitrogen adsorption-desorption methods, IR spectroscopy and thermogravimetric analysis. The XRD and BET analyses show that textural properties of SBA-15 were retained during the grafting procedure. The modified SBA was successfully applied as a heterogeneous catalyst for the synthesis of a library of nitrogen containing pyrazine based heterocycles in good to excellent yields in water media.
Bismuth(III)-catalyzed rapid synthesis of 2,3-disubstituted quinoxalines in water
Yadav, Jhillu S.,Subba Reddy, Basi V.,Premalatha, Kokku,Shankar, Kattela Shiva
, p. 3787 - 3792 (2008)
A variety of 2,3-disubstituted quinoxalines are readily prepared in high yields under extremely mild conditions by cyclocondensation of arene-1,2-diamines with 1,2-dicarbonyls using a catalytic amount of bismuth(III) triflate. The reactions of 2,3-diamino
Niobium (V) chloride: An efficient catalyst for the synthesis of quinoxalines
Venkateswarlu,Leelavathi
, p. 208 - 211 (2010)
A simple and efficient method for the synthesis of quinoxalines derivatives has been developed. All the reactions were carried out in presence of niobium (V) chloride at acetonitrile reflux conditions. The method is applicable to a variety of diketones and 1, 2-phenylenediamines to afford the corresponding derivatives in excellent yields.
Tungstophosphoric acid/mesoporous silicas as suitable catalysts in quinoxaline synthesis
Langer, Peter,Luque, Rafael,Palermo, Valeria,Pizzio, Luis R.,Romanelli, Gustavo P.,Sosa, Alexis A.
, (2021/12/16)
Quinoxalines and their derivatives are of great value in the chemical and biological sciences. These compounds are found in dyes, agrochemicals, and are used as building blocks of drugs for the treatment of different diseases. Quinoxalines and their deriv
HBTU-catalyzed simple and mild protocol for the synthesis of quinoxaline derivatives
Bhushan, B. Popatkar,Gangadhar, A. Meshram
, (2020/07/21)
HBTU-catalyzed, simple, mild, and effective protocol for the synthesis of quinoxalines has been established. The reaction between 1,2-diamines, benzil, and catalytic amount of HBTU in ethanol resulted into quinoxalines. Various aliphatic, aromatic and het
Synthesis of quinoxaline, benzimidazole and pyrazole derivatives under the catalytic influence?of biosurfactant-stabilized iron nanoparticles in water
Arde, Satyanarayan M.,Patil, Audumbar D.,Mane, Ananda H.,Salokhe, Prabha R.,Salunkhe, Rajashri S.
, p. 5069 - 5086 (2020/09/02)
Abstract: We have reported the synthesis, characterization, and catalytic applications of amorphous iron nanoparticles (FeNPs) using aqueous leaves extract of renewable natural resource Boswellia serrata plant. Synthesized FeNPs were stabilized in situ by the addition of aqueous pod extracts of Acacia concinna as a biosurfactant (pH 3.11). The structural investigation of biosynthesized nanoparticles was performed using UV–visible spectroscopy, X-ray diffraction analysis, selected area electron diffraction, energy-dispersive X-ray spectroscopy, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, and BET analysis. The FeNPs were amorphous in nature with average particle size ~ 19?nm and successfully employed as heterogeneous catalyst for the synthesis of quinoxaline, benzimidazole, and pyrazole derivatives in aqueous medium at ambient conditions. The FeNPs could be recycled up to five times with modest change in the catalytic activity. Graphic abstract: [Figure not available: see fulltext.].
