123232-63-3

Basic information

• Product Name: 1-(4'-nitrophenyl)-2-propen-1-ol
• Synonyms: 1-(4'-nitrophenyl)-2-propen-1-ol
• CAS NO: 123232-63-3
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17
• Mol File: 123232-63-3.mol
• Article Data: 31

Chemical Properties

• Melting Point: 54-55.5 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 328.2°Cat760mmHg
• Flash Point: 145.5°C
• Appearance: /
• Density: 1.244g/cm³
• PKA: 12.87±0.20(Predicted)
• CAS DataBase Reference: 1-(4'-nitrophenyl)-2-propen-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4'-nitrophenyl)-2-propen-1-ol(123232-63-3)
• EPA Substance Registry System: 1-(4'-nitrophenyl)-2-propen-1-ol(123232-63-3)

Safety Data

• Hazardous Substances Data: 123232-63-3(Hazardous Substances Data)

Usage

Description

1-(4'-nitrophenyl)-2-propen-1-ol, also known as p-nitrostyrene or 4-nitro-1-phenyl-2-propene-1-ol, is a chemical compound with the molecular formula C9H9NO3. It is a derivative of styrene, characterized by a phenyl ring with a nitro group and a hydroxyl group attached to a propene chain. 1-(4'-nitrophenyl)-2-propen-1-ol is recognized for its applications in various industries due to its unique chemical structure and properties.

Uses

Used in Organic Synthesis:
1-(4'-nitrophenyl)-2-propen-1-ol is used as a starting material or intermediate for [application reason] in the field of organic synthesis. Its unique structure allows for further chemical reactions and modifications, making it a valuable component in creating more complex molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(4'-nitrophenyl)-2-propen-1-ol is used as a starting material or intermediate for [application reason] in drug development. Its properties make it a promising candidate for the creation of new medications and therapeutic compounds.
Used in Dye Production:
1-(4'-nitrophenyl)-2-propen-1-ol is used as a chemical intermediate for [application reason] in the production of dyes. Its chemical structure contributes to the color and stability of the dyes, making it an essential component in this application.
Used in Fragrance Industry:
Within the fragrance industry, 1-(4'-nitrophenyl)-2-propen-1-ol is used as a starting material or intermediate for [application reason] in the creation of various scent compounds. Its unique chemical properties allow for the development of distinct and complex fragrances.
Used in Fine Chemicals Production:
1-(4'-nitrophenyl)-2-propen-1-ol is also utilized as a starting material or intermediate for [application reason] in the production of fine chemicals. Its versatility in chemical reactions makes it a valuable asset in this field.
Safety Precautions:
It is crucial to handle 1-(4'-nitrophenyl)-2-propen-1-ol with care, as it is considered toxic and may cause skin and eye irritation upon contact. Proper safety measures, including the use of personal protective equipment (PPE) and adherence to safety protocols, should be taken to minimize the risk of exposure and potential health hazards.

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 555-16-8 4-nitrobenzaldehdye 
• 3536-96-7 vinylmagnesium chloride 
• 1122-91-4 4-bromo-benzaldehyde 
• 71269-07-3 3-(4-nitrophenyl)-2-propenyl chloride 
• 586-78-7 para-nitrophenyl bromide 
• 107-02-8 acrolein 

Downstream Products

• 274927-71-8 (1'R,S)-1-(4-nitrophenyl)-2-propene-1-acetate 
• 782496-82-6 1-methoxymethoxy-1-(4-nitrophenyl)-2-propene 
• 914646-11-0 (S)-1-(4-nitrophenyl)-2-propen-1-ol 
• 134250-58-1 1-(4'-nitrophenyl)propane-1,3-diol 
• 782496-84-8 1-(4-nitrophenyl)propane-1,3-diamine 
• 782496-83-7 1-(4-nitrophenyl)propane-1,3-diazide 
• 782496-80-4 3-(tert-butyldiphenylsilyloxy)-1-(4-nitrophenyl)propylamine 
• 263392-93-4 3-amino-1-(4-nitrophenyl)-propan-1-ol 
• 263392-94-5 3-methoxymethoxy-3-(4-nitrophenyl)-propan-1-ol 
• 263392-92-3 3-methoxymethoxy-3-(4-nitrophenyl)-1-propylamine 
• 288580-28-9 3-methoxymethoxy-3-(4-nitrophenyl)-1-propylazide 
• 288580-26-7 3-(tert-butyldiphenylsilyloxy)-1-(4-nitrophenyl)propan-1-ol 

Relevant articles and documents

Enantioselective synthesis of 3-substituted 1,2-oxazinanes via organocatalytic intramolecular aza-Michael addition

A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er). These reactions were enabled by a quinine-derived primary-tertiary diamine as a catalyst and pentafluoropropionic acid (PFP) as a co-catalyst.

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To develop novel analgesics with no side effects or less side effects than traditional opioids is highly demanded to treat opioid receptor mediated pain and addiction issues. Recently, κ-opioid receptor (KOR) has been established as an attractive target,

Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures

We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

Manganese-Catalyzed Ring-Opening Coupling Reactions of Cyclopropanols with Enones

A manganese-catalyzed ring-opening coupling reaction of cyclopropanols with enones for the facile and efficient preparation of 1,6-diketones is described. A wide array of synthetically important 1,6-diketones bearing manifold functional groups are obtained with up to 93% yield. These reactions feature broad substrate scopes, environmentally benign conditions, inexpensive catalyst, and operational simplicity.