123367-22-6

Basic information

• Product Name: DiMethyl-[2-(4-nitro-1-oxy-pyridin-3-yl)-vinyl]-aM
• Synonyms: DiMethyl-[2-(4-nitro-1-oxy-pyridin-3-yl)-vinyl]-aM;(E)-3-(2-(DIMETHYLAMINO)VINYL)-4-NITROPYRIDINE 1-OXIDE
• CAS NO: 123367-22-6
• Molecular Formula: C₉H₁₁N₃O₃
• Molecular Weight: 209.20194
• Mol File: 123367-22-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 459.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• PKA: 6.08±0.70(Predicted)
• CAS DataBase Reference: DiMethyl-[2-(4-nitro-1-oxy-pyridin-3-yl)-vinyl]-aM(CAS DataBase Reference)
• NIST Chemistry Reference: DiMethyl-[2-(4-nitro-1-oxy-pyridin-3-yl)-vinyl]-aM(123367-22-6)
• EPA Substance Registry System: DiMethyl-[2-(4-nitro-1-oxy-pyridin-3-yl)-vinyl]-aM(123367-22-6)

Safety Data

• Hazardous Substances Data: 123367-22-6(Hazardous Substances Data)

Upstream product

• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1003-73-2 3-picoline-N-oxide 
• 3616-57-7 2,2-diethoxy-N,N-diethylethanamine 
• 108-99-6 3-Methylpyridine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 271-34-1 5-azaindole 
• 266353-32-6 4-nitro-3-pyridinecarbaldehyde 1-oxide 
• 148760-75-2 tert-butyl 1H-pyrrolo[3,2-c]pyridine-1-carboxylate 
• 848410-13-9 tert-butyl (3aS,7aR)-2,3,3a,4,5,6,7,7a-octahydropyrrolo[3,2-c]pyridine-1-carboxylate 
• 42373-30-8 4-aminonicotinaldehyde 
• 109113-39-5 1-Benzenesulfonyl-1H-pyrrolo<3,2-c>pyridine 
• 109113-44-2 1-Benzenesulfonyl-2-formyl-1H-pyrrolo<3,2-c>pyridine 
• 109113-41-9 1-benzenesulphonyl-2-acetyl-1H-pyrrolo[3,2-c]pyridine 
• 109113-45-3 1-Benzenesulfonyl-2-hydroxycarbonyl-1H-pyrrolo<3,2-c>pyridine 
• 125335-95-7 2-(1-Benzenesulfonyl-1H-pyrrolo<3,2-c>pyridine)-4-(3-diethylaminocarbonyl-2-methoxypyridyl)ketone 
• 148729-71-9 2-(1-Benzenesulfonyl-1H-pyrrolo<3,2-c>pyridine)-4-(3-diethylaminocarbonyl-2-methoxypyridyl)methanol 
• 148729-73-1 2-(1-Benzenesulfonyl-1H-pyrrolo<3,2-c>pyridine)-4-(3-diethylaminocarbonyl-2-methoxypyridyl)-1,1-ethanol 

Relevant articles and documents

4-Aminopyridine derivatives with antiamnesic activity

Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4- aminopyridine (4-AP). 4-AP is also the central ring of tacrine, the first drug approved for the treatment of AD. The synthesis and pharmacological activity of three 4-AP derivatives, prepared with the aim of improving their antiamnesic activity, is here described. In two of these compounds 4-AP is connected to 4-aminobutyric acid (GABA), whereas in the third it is connected to 2-indolinone, i.e., the skeleton of linopirdine, another Ach enhancing agent. The new compounds showed potent antiamnesic activity in comparison with piracetam. (C) 2000 Edition scientifiques et medicales Elsevier SAS.

Design, synthesis and antiproliferative activity evaluation of new 5-azaisoindigo derivatives

New 5-azaisoindigo derivatives were synthesized with two key intermediates 5-azaoxindole (7) and substituted indole-2,3-dione (10) in this paper. Intermediate 7 was prepared from 3-methylpyridine (1) through 6 steps containing oxidation reaction and so on. Intermediate 10 was obtained by a convenient Sandmeyer's method. The target compounds 5-azaisoindigo derivatives 11a-f were obtained by condensation of these two intermediates 7 and 10 in acidic condition. All target compounds were evaluated for their antiproliferative activity against seven cell lines by SRB assay. Compounds 11e and 11f showed significant antiproliferative activity against K562 cells (IC50: 8.9 μM and 13.6 μM, respectively).

NOVEL COMPOUNDS

The present invention relates to new CGRP-antagonists of general formula I wherein U, V, X, Y, R1, R2, R3 and R4 are defined as in the description, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing these compounds, their use and processes for preparing them.