1233943-89-9Relevant articles and documents
One-step synthesis of 1-(4,5-diphenylpyrimidin-2-yl)thiourea
Han, Wen-Yong,Zhang, Zun-Ting,Zhang, Ying-Chun,Xue, Dong,Li, Gang
experimental part, p. 1641 - 1649 (2010/12/24)
A simple and straightforward methodology toward the synthesis of novel 1-(4,5-diphenylpyrimidin-2-yl)thiourea has been developed by a one-step reaction of isoflavones with amidinothiourea. A series of 16 new compounds was synthesized. All compounds were characterized by FT-IR, NMR, and elemental analysis. The structure of a typical compound was established by X-ray diffraction. Avariety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery.