123426-26-6Relevant articles and documents
Synthesis and crystallographic insight into the structural aspects of some novel adamantane-based ester derivatives
Kumar, C.S. Chidan,Kwong, Huey Chong,Mah, Siau Hui,Chia, Tze Shyang,Loh, Wan-Sin,Quah, Ching Kheng,Lim, Gin Keat,Chandraju, Siddegowda,Fun, Hoong-Kun
, p. 18827 - 18846 (2015)
Adamantyl-based compounds are commercially important in the treatments for neurological conditions and type-2 diabetes, aside from their anti-viral abilities. Their values in drug design are chronicled as multi-dimensional. In the present study, a series of 2-(adamantan-1-yl)-2-oxoethyl benzoates, 2(a-q), and 2-(adamantan-1-yl)-2-oxoethyl 2-pyridinecarboxylate, 2r, were synthesized by reacting 1-adamantyl bromomethyl ketone with various carboxylic acids using potassium carbonate in dimethylformamide medium at room temperature. Three-dimensional structures studied using X-ray diffraction suggest that the adamantyl moiety can serve as an efficient building block to synthesize 2-oxopropyl benzoate derivatives with synclinal conformation with a looser-packed crystal packing system. Compounds 2a, 2b, 2f, 2g, 2i, 2j, 2m, 2n, 2o, 2q and 2r exhibit strong antioxidant activities in the hydrogen peroxide radical scavenging test. Furthermore, three compounds, 2p, 2q and 2r, show good anti-inflammatory activities in the evaluation of albumin denaturation.
INTRODUCTION D'UN SYSTEME "CAGE" DERIVE DE L'ADAMANTANE DANS LES ACIDES CARBOXYLIQUES, PAR ALKYLATION EN CATALYSE PAR TRANSFERT DE PHASE ET PAR UNE METHODE NON CATALYTIQUE
Hedayatullah, Mir
, p. 139 - 144 (2007/10/02)
The syntheses of new carboxylic esters of general type RCO2-CH2CO-Ad (Ad = 1-adamantyl), where R may be aliphatic or aromatic, have been achieved in high yield by reaction of the corresponding acides with an appropriate derivative of adamantane under phas
