1234491-48-5

Basic information

• Product Name: 2,2-dimethylpropyl (2S)-2-((((2R,3R,4R,5R)-5-(2-amino-6-benzylamino-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphorylamino)propionate
• CAS NO: 1234491-48-5
• Molecular Weight: 733.761
• Mol File: 1234491-48-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2-dimethylpropyl (2S)-2-((((2R,3R,4R,5R)-5-(2-amino-6-benzylamino-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphorylamino)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethylpropyl (2S)-2-((((2R,3R,4R,5R)-5-(2-amino-6-benzylamino-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphorylamino)propionate(1234491-48-5)
• EPA Substance Registry System: 2,2-dimethylpropyl (2S)-2-((((2R,3R,4R,5R)-5-(2-amino-6-benzylamino-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphorylamino)propionate(1234491-48-5)

Safety Data

• Hazardous Substances Data: 1234491-48-5(Hazardous Substances Data)

Upstream product

• 641571-44-0 (2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(benzoyloxymethyl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate 
• 15397-15-6 1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose 
• 1234489-09-8 (S)-2-[chloro-(naphthalen-1-yloxy)-phosphorylamino]-propionic acid 2,2-dimethyl propyl ester 
• 1234491-47-4 (2R,3R,4R,5R)-2-(2-amino-6-(benzylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol 

Relevant articles and documents

Dual pro-drugs of 2′-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus

We have previously reported the power of combining a 5′- phosphoramidate ProTide, phosphate pro-drug, motif with a 6-methoxy purine pro-drug entity to generate highly potent anti-HCV agents, leading to agents in clinical trial. We herein extend this work with the disclosure that a variety of alternative 6-substituents are tolerated. Several compounds exceed the potency of the prior 6-methoxy leads, and in almost every case the ProTide is several orders of magnitude more potent than the parent nucleoside. We also demonstrate that these agents act as pro-drugs of 2′-C-methyl guanosine monophosphate. We have also reported the novel use of hepatocyte cell lysate as an ex vivo model for ProTide metabolism.