123542-78-9Relevant articles and documents
A New Approach to Enantiomerically Pure β-Lactams from α-Amino Acids by Applying the Isonitrile-Nitrile Rearrangement
Haaf, Klaus,Ruechardt, Christoph
, p. 635 - 638 (2007/10/02)
(S)-Phenylalanine (1) was converted into (S)-3-benzyl-2-azetidinone (8b) by a multistep reaction sequence.The key step of this approach is a stereospecific isonitrile-nitrile rearrangement ( 3 -> 4) by flash pyrolysis, which may be performed in 20-g batch