1236144-51-6

Basic information

• Product Name: 1-benzyl 3-tert-butyl azetidine-1,3-dicarboxylate
• Synonyms: 1-benzyl 3-tert-butyl azetidine-1,3-dicarboxylate
• CAS NO: 1236144-51-6
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.34224
• Mol File: 1236144-51-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-benzyl 3-tert-butyl azetidine-1,3-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl 3-tert-butyl azetidine-1,3-dicarboxylate(1236144-51-6)
• EPA Substance Registry System: 1-benzyl 3-tert-butyl azetidine-1,3-dicarboxylate(1236144-51-6)

Safety Data

• Hazardous Substances Data: 1236144-51-6(Hazardous Substances Data)

Usage

Chemical structure

A central azetidine ring with two carboxylate groups attached, along with a benzyl and tert-butyl group.

Molecular weight

Approximately 315.4 g/mol

Functional groups

Carboxylate, benzyl, and tert-butyl groups.

Appearance

A colorless to pale yellow solid or liquid, depending on the temperature and concentration.

Solubility

Soluble in organic solvents such as dichloromethane, ethyl acetate, and acetone.

Stability

Stable under normal temperature and pressure, but sensitive to heat, light, and moisture.

Reactivity

Reacts with various reagents to form different derivatives, making it a versatile intermediate in organic synthesis.

Applications

Used in the synthesis of various drugs and pharmaceuticals, as well as in medicinal chemistry for the preparation of complex molecules.

Pharmacological activity

Exhibits potential pharmacological activity, making it valuable in drug discovery and development.

Safety precautions

Handle with care, as it may be harmful if inhaled, ingested, or absorbed through the skin. Use appropriate personal protective equipment (PPE) and follow proper storage and disposal guidelines.

Hazardous properties

May be classified as an irritant or toxicant, depending on the specific concentration and exposure levels. Consult the material safety data sheet (MSDS) for detailed information on hazards and safety precautions.

Upstream product

• 75-65-0 tert-butyl alcohol 
• 97628-92-7 1-benzyloxycarbonyl-3-azetidinecarboxylic acid 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 757239-60-4 O₁-benzyl-O₃-methylazetidine-1,3-dicarboxylate 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1236144-52-7 tert-butyl azetidine-3-carboxylate acetic acid salt 
• 1265323-63-4 tert-butyl 1-(2-(4-cyanophenyl)-2-oxoethyl)azetidine-3-carboxylate 
• 1265323-47-4 tert-butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate 
• 1307812-56-1 tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)-azetidine-3-carboxylate 
• 1307813-46-2 tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate 
• 1307813-53-1 tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate 
• 1307813-63-3 tert-butyl 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)methyl)azetidine-3-carboxylate 
• 1307813-93-9 tert-butyl ester-1-((8-fluoro-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid 
• 1236144-54-9 (Z)-tert-butyl 1-(4-(N-hydroxycarbamimidoyl)benzyl)azetidine-3-carboxylate 
• 1236144-53-8 tert-butyl 1-(4-cyanobenzyl)azetidine-3-carboxylate 
• 1356464-97-5 tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)ethyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate 
• 1356465-00-3 (E)-tert-butyl 1-(4-(5-(2-(1-(3,4-difluorophenyl)cyclohexyl)vinyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate 
• 1356465-29-6 tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate 
• 1236189-59-5 tert-butyl 1-(4-(5-(4-(1,1-difluoroethyl)-5-phenylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate 

Relevant articles and documents

AMINOESTER DERIVATIVES

The invention relates to novel compounds which are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY

The present invention relates to compounds acting both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists, to processes for their preparation, to compositions comprising them, to therapeutic uses and combinations with other pharmaceutical active ingredients.

SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS

Disclosed are compounds of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: A is formula (II) Q is a substituted 5-membered monocyclic heteroaryl group; W is CH2, O, or NH; and R1, R2, R3, R4, R5, R6, m, n, t, and x are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.