123637-16-1

Basic information

• Product Name: (S)-2-{4-[(2-Chloro-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid
• Synonyms: (S)-2-{4-[(2-Chloro-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid
• CAS NO: 123637-16-1
• Molecular Weight: 479.92
• Mol File: 123637-16-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-{4-[(2-Chloro-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-{4-[(2-Chloro-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid(123637-16-1)
• EPA Substance Registry System: (S)-2-{4-[(2-Chloro-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid(123637-16-1)

Safety Data

• Hazardous Substances Data: 123637-16-1(Hazardous Substances Data)

Upstream product

• 123637-77-4 6-bromomethyl-2-chloro-quinoline 
• 106-49-0 p-toluidine 
• 4295-11-8 2-chloro-6-methylquinoline 
• 4053-34-3 6-methylquinolin-2(1H)-one 

Relevant articles and documents

Quinoline antifolate thymidylate synthase inhibitors: Variation of the C2- and C4-substituents

Modifications to the bicyclic ring system of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(2-amino-3,4-dihydro-4-oxo-6- quinazolinyl)methyl]-N-prop-2-ynylamino]benzoyl]-L-glutamic acid (1, CB3717) have led to the synthesis of a series of quinol