123696-02-6 Usage
Description
3-Chloro-5-methoxypyridazine is an organic compound with the molecular formula C5H5ClN2O. It is a heterocyclic compound featuring a pyridazine ring with a chloro group at the 3rd position and a methoxy group at the 5th position. 3-CHLORO-5-METHOXYPYRIDAZINE serves as an important intermediate in the synthesis of various pharmaceuticals and biologically active molecules due to its unique structural properties.
Uses
Used in Pharmaceutical Industry:
3-Chloro-5-methoxypyridazine is used as a key intermediate in the synthesis of potent and selective inhibitors of glycogen synthase kinase 3 (GSK-3) for the development of new therapeutic agents. GSK-3 is a serine/threonine protein kinase that plays a crucial role in various cellular processes, including glycogen synthesis, cell cycle regulation, and apoptosis. Inhibition of GSK-3 has been linked to the treatment of several diseases, such as Alzheimer's, diabetes, and cancer.
The compound's application in the pharmaceutical industry is primarily due to its ability to be incorporated into the molecular structure of GSK-3 inhibitors, which can exhibit good cellular efficacy. This makes 3-chloro-5-methoxypyridazine a valuable building block for the design and development of novel therapeutics targeting GSK-3-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 123696-02-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,6,9 and 6 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 123696-02:
(8*1)+(7*2)+(6*3)+(5*6)+(4*9)+(3*6)+(2*0)+(1*2)=126
126 % 10 = 6
So 123696-02-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H5ClN2O/c1-9-4-2-5(6)8-7-3-4/h2-3H,1H3
123696-02-6Relevant articles and documents
ErbB RECEPTOR INHIBITORS AS ANTI-TUMOR AGENTS
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Page/Page column 164; 165, (2021/09/17)
Provided herein are novel compounds as inhibitors of type I receptor tyrosine kinases, the pharmaceutical compositions comprising one or more of the compounds and salts thereof as an active ingredient, and the use of the compounds and salts thereof in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals and especially in humans.
HETEROARYLBENZIMIDAZOLE COMPOUNDS
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Page/Page column 455; 456, (2017/07/06)
The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
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Page/Page column 119, (2012/09/11)
The invention relates to benzamide derivatives of formula (I),wherein R1, R2, R3, R4, R5, R6, n and Y are as defined in the description, their preparation and their use as pharmaceutically active compounds.
