1238-09-1

Basic information

• Product Name: H-PHE-ARG-OH TRIFLUOROACETATE SALT
• Synonyms: H-PHE-ARG-OH TFA;H-PHE-ARG-OH TRIFLUOROACETATE SALT;H-PHE-ARG-OH;phenylalanylarginine;Bradykinin(8-9);L-Phe-L-Arg-OH;Nα-(L-Phenylalanyl)-L-arginine;Phe-Arg-OH
• CAS NO: 1238-09-1
• Molecular Formula: C₁₅H₂₃N₅O₃
• Molecular Weight: 435.4
• Mol File: 1238-09-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.35g/cm³
• Refractive Index: 1.622
• Storage Temp.: -15°C
• PKA: pK1:2.66(+1);pK2:7.57(0);pK3:12.40(-1) (25°C,μ=0.01)
• CAS DataBase Reference: H-PHE-ARG-OH TRIFLUOROACETATE SALT(CAS DataBase Reference)
• NIST Chemistry Reference: H-PHE-ARG-OH TRIFLUOROACETATE SALT(1238-09-1)
• EPA Substance Registry System: H-PHE-ARG-OH TRIFLUOROACETATE SALT(1238-09-1)

Safety Data

• Hazardous Substances Data: 1238-09-1(Hazardous Substances Data)

Usage

Description

H-PHE-ARG-OH TRIFLUOROACETATE SALT, also known as L-phenylalanine-L-arginine dipeptide trifluoroacetate salt, is a synthetic dipeptide consisting of L-phenylalanine and L-arginine joined by a peptide linkage. It is a water-soluble, stable, and bioactive compound with potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
H-PHE-ARG-OH TRIFLUOROACETATE SALT is used as a pharmaceutical candidate for its potential therapeutic effects. The dipeptide has been found to exhibit anti-inflammatory, antioxidant, and immunomodulatory properties, making it a promising agent for the treatment of various diseases, including inflammatory disorders, neurodegenerative diseases, and cancer.
Used in Cosmetic Industry:
In the cosmetic industry, H-PHE-ARG-OH TRIFLUOROACETATE SALT is used as an active ingredient for its skin-protecting and anti-aging properties. The dipeptide can help improve skin elasticity, reduce the appearance of fine lines and wrinkles, and protect the skin from environmental stressors, such as UV radiation and pollution.
Used in Food and Nutrition Industry:
H-PHE-ARG-OH TRIFLUOROACETATE SALT is used as a functional ingredient in food and nutrition products for its potential health benefits. The dipeptide can enhance protein synthesis, support muscle growth and recovery, and improve overall physical performance. It can also be used as a flavor enhancer and a natural preservative in various food products.
Used in Agricultural Industry:
In agriculture, H-PHE-ARG-OH TRIFLUOROACETATE SALT is used as a biostimulant to promote plant growth and improve crop yield. The dipeptide can enhance nutrient uptake, stimulate root development, and increase stress resistance in plants, leading to healthier and more productive crops.
Overall, H-PHE-ARG-OH TRIFLUOROACETATE SALT is a versatile and bioactive dipeptide with potential applications in various industries, including pharmaceutical, cosmetic, food and nutrition, and agricultural sectors. Its unique properties and benefits make it a valuable compound for research and development in these fields.

InChI:InChI=1/C15H23N5O3/c16-11(9-10-5-2-1-3-6-10)13(21)20-12(14(22)23)7-4-8-19-15(17)18/h1-3,5-6,11-12H,4,7-9,16H2,(H,20,21)(H,22,23)(H4,17,18,19)

Upstream product

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• 35661-40-6 N-Fmoc L-Phe 
• 74-79-3 L-arginine 
• 17543-49-6 (S)-benzyloxycarbonylphenylalanine pentafluorophenyl ester 
• 7535-56-0 N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 
• 3674-06-4 (tert-butoxycarbonyl)-L-phenylalanine N-hydroxysuccinimide ester 
• 74-79-3 L-arginine 
• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 
• 187618-60-6 Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine 
• 2578-85-0 p-nitrophenyl N-(benzyloxycarbonyl)-D-phenylalaninate 

Downstream Products

• 74838-84-9 [3-(5-benzyl-3,6-dioxo-piperazin-2-yl)-propyl]-guanidine 
• 119459-99-3 (S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid 
• 88830-91-5 Dnp-Gly-Gly-Phe-Arg-OH 
• 195521-93-8 Z-Ala-Phe-Arg-OH 
• 803706-22-1 Z-Asp(OBzl)-Phe-Arg-OH 
• 195521-95-0 Boc-Cys(Acm)-Ala-Phe-Arg-OH 
• 195522-05-5 Boc-Cys(Acm)-Ala-Phe-Arg-Gln-Val-Cys(Acm)-NHEt 
• 116685-18-8 Ala-Phe-Arg 
• 119439-70-2 C₅₈H₉₅N₁₇O₁₉S 
• 119460-00-3 (S)-2-{(S)-2-[(S)-3-tert-Butoxy-2-((S)-2-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid 
• 125510-00-1 (S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-amino-propionylamino]-3-carbamoyl-propionylamino}-3-hydroxy-propionylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid 
• 119460-01-4 (S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-carbamoyl-propionylamino}-3-hydroxy-propionylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid 

Relevant articles and documents

The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme

Enzyme-inhibitor recognition is considered one of the most fundamental aspects in the area of drug discovery. However, the molecular mechanism of this recognition process (induced fit or prebinding and adaptive selection among multiple conformers) in several cases remains unexplored. In order to shed light toward this step of the recognition process in the case of human angiotensin I converting enzyme (hACE) and its inhibitor captopril, we have established a novel combinatorial approach exploiting solution NMR, flexible docking calculations, mutagenesis, and enzymatic studies. We provide evidence that an equimolar ratio of the cis and trans states of captopril exists in solution and that the enzyme selects only the trans state of the inhibitor that presents architectural and stereoelectronic complementarity with its substrate binding groove.

γ-Valerolactone (GVL): An eco-friendly anchoring solvent for solid-phase peptide synthesis

Due to the hazardous nature of CH2Cl2, regulatory authorities have imposed restrictions to minimize or even stop its use. It has therefore become imperative to identify environmentally benign solvents to replace it. Here we report on a bio derived solvent, γ-valerolactone, for the incorporation of the first amino acid onto p-alkoxybenzyl alcohol resin in solid-phase peptide synthesis. Satisfactory loading values (by a spectrophotometric method) were achieved. Furthermore, racemization and dipeptide formation were also checked and found to be acceptable.

Trends in asymmetric Michael reactions catalysed by tripeptides in combination with an achiral additive in different solvents

The potential of tripeptides 3, 6 and 12 as chiral catalysts for asymmetric Michael addition reactions in the presence of an achiral additive has been tested in different solvents (CHCI3, acetone, DMF, DMSO and the room-temperature ionic liquid