1240470-84-1

Basic information

• Product Name: rac AMbrisentan Methyl Ester
• Synonyms: rac AMbrisentan Methyl Ester;α-[(4,6-DiMethyl-2-pyriMidinyl)oxy]-β-Methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester
• CAS NO: 1240470-84-1
• Molecular Formula: C23H24N2O4
• Molecular Weight: 392.44766
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1240470-84-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 553.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.177±0.06 g/cm3(Predicted)
• PKA: 1.93±0.30(Predicted)
• CAS DataBase Reference: rac AMbrisentan Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: rac AMbrisentan Methyl Ester(1240470-84-1)
• EPA Substance Registry System: rac AMbrisentan Methyl Ester(1240470-84-1)

Safety Data

• Hazardous Substances Data: 1240470-84-1(Hazardous Substances Data)

Usage

Uses

Protected Ambrisentan.

Upstream product

• 178306-47-3 2-hydroxy-3-methoxy-3,3-diphenylpropionicacid methyl ester 
• 35144-22-0 4,6-dimethyl-2-methylsulfonylpyrimidine 
• 119-61-9 benzophenone 
• 76527-25-8 3,3-diphenyloxirane-2-carboxylic acid methyl ester 
• 298-06-6 O,O-Diethyl hydrogen phosphorodithioate 
• 178306-51-9 (S)-2-hydroxy-3-methoxy-3,3-diphenyl propionic acid 
• 178306-52-0 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid 
• 177036-94-1 ambrisentan 
• 74-88-4 methyl iodide 
• 177036-78-1 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 876148-89-9 ethyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate 
• 1431363-04-0 methyl 3-methoxy-2-oxo-3,3-diphenylpropionate 

Downstream Products

• 177036-94-1 ambrisentan 
• 1231755-51-3 (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt 
• 108-79-2 4,6-dimethyl-2(1H)-pyrimidinone 
• 177036-94-1 ambrisentan 

Relevant articles and documents

An improved method of preparing Anritsu tezosentan

The invention belongs to the field of chemical synthesis, and discloses an improved method used for preparing ambrisentan. According to the improved method, 2-hydroxy-3-methoxy-3,3-diphenylpropionic ester and 4,6-dimethyl-2-methylsulfonylpyrimidine are su

Process for the Preparation of an Endothelin Receptor Antagonist

The present invention relates to a novel process for the preparation of a compound of formula (I) wherein R is a methyl or methoxy group; to certain novel intermediates prepared in such a process and their use.

Synthesis of (+)-ambrisentan via chiral ketone-catalyzed asymmetric epoxidation

The synthesis of optically pure (+)-ambrisentan has been achieved from 3,3-diphenylacrylate in four steps with 53% overall yield and >99% ee at the >100 g scale without column purification. The chiral epoxide intermediate was prepared via asymmetric epoxi