1241977-25-2

Basic information

• Product Name: 2-(4-fluorophenyl)-6-methoxyquinoline
• Synonyms: 2-(4-fluorophenyl)-6-methoxyquinoline
• CAS NO: 1241977-25-2
• Molecular Weight: 253.276
• Mol File: 1241977-25-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-6-methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-6-methoxyquinoline(1241977-25-2)
• EPA Substance Registry System: 2-(4-fluorophenyl)-6-methoxyquinoline(1241977-25-2)

Safety Data

• Hazardous Substances Data: 1241977-25-2(Hazardous Substances Data)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 104-94-9 4-methoxy-aniline 
• 67-68-5 dimethyl sulfoxide 
• 79-24-3 Nitroethane 
• 459-57-4 4-fluorobenzaldehyde 
• 13676-02-3 2-chloro-6-methoxyquinoline 
• 1765-93-1 4-fluoroboronic acid 
• 459-56-3 4-fluorobenzylic alcohol 
• 109-92-2 ethyl vinyl ether 

Relevant articles and documents

Iron Single Atom Catalyzed Quinoline Synthesis

The production of high-value chemicals by single-atom catalysis is an attractive proposition for industry owing to its remarkable selectivity. Successful demonstrations to date are mostly based on gas-phase reactions, and reports on liquid-phase catalysis are relatively sparse owing to the insufficient activation of reactants by single-atom catalysts (SACs), as well as, their instability in solution. Here, mechanically strong, hierarchically porous carbon plates are developed for the immobilization of SACs to enhance catalytic activity and stability. The carbon-based SACs exhibit excellent activity and selectivity (≈68%) for the synthesis of substituted quinolines by a three-component oxidative cyclization, affording a wide assortment of quinolines (23 examples) from anilines and acetophenones feedstock in an efficient, atom-economical manner. Particularly, a Cavosonstat derivative can be synthesized through a one-step, Fe1-catalyzed cyclization instead of traditional Suzuki coupling. The strategy is also applicable to the deuteration of quinolines at the fourth position, which is challenging by conventional methods. The synthetic utility of the carbon-based SAC, together with its reusability and scalability, renders it promising for industrial scale catalysis.

Amine compound for inhibiting SSASASASASASASAO/VAP-1 and application thereof in medicine (by machine translation)

The invention relates to an amine compound serving as an amino urea-sensitive amine oxidase (SSASAO) and/or a vascular adhesion protein -1 (VAP AP AP-1) inhibitor and application thereof in medicine, and further relates to a pharmaceutical composition containing the compound. The compounds or pharmaceutical compositions described herein may be used to treat inflammation and/or inflammation related diseases, diabetes and/or diabetes-related diseases, psychiatric disorders, ischemic diseases, vascular diseases, fibrosis or tissue transplant rejection. (by machine translation)