1242241-51-5Relevant articles and documents
Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency
Qian, Wenyuan,Chen, Jian Jeffrey,Human, Jason,Aya, Toshihiro,Zhu, Jiawang,Biswas, Kaustav,Peterkin, Tanya,Hungate, Randall W.,Arik, Leyla,Johnson, Eileen,Kumar, Gondi,Joseph, Smriti,Jona, Janan,Guo, Hong-Xun,Wu, Zufan
scheme or table, p. 1061 - 1067 (2012/03/11)
In a series of bradykinin B1 antagonists, we discovered that replacement of oxopiperazine acetamides with dehydro-oxopiperazine acetamides provided compounds with enhanced activity against the B1 receptor. The synthesis and SAR leading to potent analogs w