124340-89-2

Basic information

• Product Name: 1H-Benzimidazole-7-carboxylic acid, 2-(3-pyridinyl)-
• Synonyms: 1H-Benzimidazole-7-carboxylic acid, 2-(3-pyridinyl)-;2-(pyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid
• CAS NO: 124340-89-2
• Molecular Formula: C₁₃H₉N₃O₂
• Molecular Weight: 239.23
• Mol File: 124340-89-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazole-7-carboxylic acid, 2-(3-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-7-carboxylic acid, 2-(3-pyridinyl)-(124340-89-2)
• EPA Substance Registry System: 1H-Benzimidazole-7-carboxylic acid, 2-(3-pyridinyl)-(124340-89-2)

Safety Data

• Hazardous Substances Data: 124340-89-2(Hazardous Substances Data)

Usage

Chemical structure

1H-Benzimidazole-7-carboxylic acid, 2-(3-pyridinyl)consists of a benzimidazole ring with a carboxylic acid group at position 7 and a 2-(3-pyridinyl) group attached to the nitrogen at position 2 of the benzimidazole ring.

Usage

Commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals.

Biological activities

Studied for its potential as an inhibitor of protein kinases and as a potential anti-cancer agent.

Versatility

Presence of both a benzimidazole and a pyridinyl moiety makes it a potentially valuable chemical for various applications in medicinal chemistry and pharmacology.

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 603-81-6 2,3-diaminobenzoic acid 
• 606-18-8 3-nitroanthranilic acid 
• 77326-45-5 2-carbamoyl-3-nitrobenzoic acid 
• 61063-11-4 2-Amino-3-nitrobenzoic acid,ethyl ester 
• 16533-45-2 ethyl 2-carboxy-3-nitrobenzoate 
• 136285-66-0 3-nitro-phthalic acid-1-ethyl ester-2-chloride 
• 124341-05-5 2-Azidocarbonyl-3-nitro-benzoic acid ethyl ester 
• 641-70-3 3-nitrophthalic acid anhydride 
• 603-11-2 3-nitrophthalic acid 

Downstream Products

• 1309042-22-5 (L)-2-(pyridin-3-yl)-N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)-1H-benzimidazole-4-carboxamide 

Relevant articles and documents

Synthesis and biological evaluation of novel benzimidazole derivatives bearing a heterocyclic ring at 4/5 position

A series of novel benzimidazole derivatives bearing a heterocyclic ring as oxadiazole (21-32), thiadiazole (33-34), triazole (35-36) were synthesized and evaluated for their activities against Coxsackie virus B3 and B6 in Vero cells. Compounds 21-26, 31-36 with moieties of 2'-pyridyl, 3'-pyridyl and 4'-pyridyl at the 2-position and oxadiazoles, thiadiazole, or triazole substituent at the 4- or 5-position generally displayed activities against CVB3 and CVB6. Especially compound 24 (IC50 = 1.08 μg/mL, SI = 61.7 against CVB3) was the promising candidate as lead compound for anti-enteroviral drug. It was observed in the incorporation of heterocyclic rings in benzimidazole at the 5-position could enhance their biological activities.

Convenient method for the preparation of 2-aryl-1H-benzimidazole-4- carboxylic acids

The oxidative cyclization of 2,3-diaminobenzoic acid and aromatic aldehydes to give 2-aryl-1H-benzimidazole-4-carboxylic acids is reported. Moreover, three methods were compared in different perspectives from experimental manipulation to yield. Copyright

Benzamide derivatives having a vasopressin antagonistic activity

This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I): wherein R1is aryl optionally substituted with lower alkoxy, etc., R2is lower alkyl, etc., R3is hydrogen, etc., A is NH, etc., E is etc., X is —CH═CH—, —CH═N—, or S, and Y is a condensed heterocyclic group, etc., and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.