124345-10-4

Basic information

• Product Name: 4-(3,4-Dichlorophenyl)-2-hydroxy-3,4-dihydro-2H-naphthalen-1-one
• Synonyms: 4-(3,4-DICHLORO-PHENYL)-2-HYDROXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;1-Des(methylamine)-1-oxo-2-(R,S)-hydroxySertraline;4-(3,4-Dichlorophenyl)-3,4-dihydro-2-(R,S)-hydroxy-2H-naphthalen-1-one;4-(S)-(3,4-Dichlorophenyl)-3,4-dihydro-2-(R,S)-hydroxy-2H-naphthalen-1-one;4-(S)-1-Des(methylamine)-1-oxo-2-(R,S)-hydroxy Sertraline;4-(3,4-DICHLORO-PHENYL)-2-HYDROXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE, 98+%;(2R-trans)-4-(3,4-Dichlorophenyl)-3,4-dihydro-2-hydroxy-1(2H)-naphthalenone;4-(3,4-Dichlorophenyl)-2-hydroxy-3,4-dihydronaphthalen-1(2H)-one
• CAS NO: 124345-10-4
• Molecular Formula: C16H12Cl2O2
• Molecular Weight: 307.17
• Product Categories: Metabolites
• Mol File: 124345-10-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 451.1 °C at 760 mmHg
• Flash Point: 226.6 °C
• Appearance: /
• Density: 1.41g/cm³
• Refractive Index: 1.645
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-(3,4-Dichlorophenyl)-2-hydroxy-3,4-dihydro-2H-naphthalen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-Dichlorophenyl)-2-hydroxy-3,4-dihydro-2H-naphthalen-1-one(124345-10-4)
• EPA Substance Registry System: 4-(3,4-Dichlorophenyl)-2-hydroxy-3,4-dihydro-2H-naphthalen-1-one(124345-10-4)

Safety Data

• Hazardous Substances Data: 124345-10-4(Hazardous Substances Data)

Usage

Description

4-(3,4-Dichlorophenyl)-2-hydroxy-3,4-dihydro-2H-naphthalen-1-one is a chemical compound derived from Sertraline, a widely prescribed antidepressant medication. It is characterized by its dark orange oil appearance and a specific rotation of +41.1o (c = 0.11, chloroform). 4-(3,4-Dichlorophenyl)-2-hydroxy-3,4-dihydro-2H-naphthalen-1-one is known for its chemical properties and potential applications in various fields.

Uses

1. Pharmaceutical Industry:
4-(3,4-Dichlorophenyl)-2-hydroxy-3,4-dihydro-2H-naphthalen-1-one is used as a metabolite in the pharmaceutical industry for the development and understanding of Sertraline's effects on the human body. As a metabolite, it plays a crucial role in the study of drug metabolism, pharmacokinetics, and potential side effects associated with Sertraline use.
2. Research and Development:
In the field of research and development, 4-(3,4-Dichlorophenyl)-2-hydroxy-3,4-dihydro-2H-naphthalen-1-one serves as a valuable compound for exploring new therapeutic applications and potential drug interactions. Its chemical properties make it an interesting subject for further investigation into its pharmacological properties and possible uses in the treatment of various medical conditions.
3. Quality Control and Analysis:
The specific rotation value of +41.1o (c = 0.11, chloroform) for this compound makes it a useful reference in the quality control and analysis of Sertraline and its related products. This parameter can be employed to ensure the purity and consistency of Sertraline in pharmaceutical formulations, as well as to monitor the efficiency of manufacturing processes.

InChI:InChI=1/C16H12Cl2O2/c17-13-6-5-9(7-14(13)18)12-8-15(19)16(20)11-4-2-1-3-10(11)12/h1-7,12,15,19H,8H2