1245079-22-4 Usage
Description
[(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester is a chiral pyrrolidine derivative featuring a tert-butyl carbamate ester group. [(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester is characterized by its (3R,4S) isomer, which is the active form. The incorporation of a difluorophenyl group endows it with unique pharmacological properties, making it a promising candidate for drug design. The tert-butyl ester group not only enhances its lipophilicity but also has the potential to influence its pharmacokinetic properties.
Uses
Used in Medicinal Chemistry:
[(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique structural features and potential biological activities. [(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester's chirality, difluorophenyl group, and tert-butyl ester functionality contribute to its value in drug design, allowing for the development of new therapeutic agents with improved efficacy and selectivity.
Used in Drug Design and Development:
In the pharmaceutical industry, [(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester is used as a building block for creating novel drug candidates. Its structural attributes, including the chiral center and the difluorophenyl group, make it an attractive starting point for the design of new medications with potential applications in various therapeutic areas, such as central nervous system disorders, cardiovascular diseases, and oncology.
Used in Drug Delivery Systems:
[(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester can be utilized in the development of drug delivery systems to improve the bioavailability and pharmacokinetic properties of other therapeutic agents. Its lipophilic nature and the ability to form stable prodrugs or drug conjugates make it a suitable candidate for enhancing the delivery and targeting of drugs to specific tissues or cells, potentially improving their therapeutic index and reducing side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1245079-22-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,0,7 and 9 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1245079-22:
(9*1)+(8*2)+(7*4)+(6*5)+(5*0)+(4*7)+(3*9)+(2*2)+(1*2)=144
144 % 10 = 4
So 1245079-22-4 is a valid CAS Registry Number.
1245079-22-4Relevant articles and documents
1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS
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, (2013/03/26)
Therapeutic compounds are disclosed having the general formula (I) that are useful for the treatment of metabolic disorders, including type II diabetes. The compounds have activity as agonists of GPR1 19. Compounds having stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.
CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS
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Page/Page column 46, (2011/12/14)
Therapeutic compounds are disclosed having the general formula (I) that are useful for the treatment of metabolic disorders, including type II diabetes. The compounds have activity as agonists of GPR119. Compounds having the stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.
COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
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Page/Page column 42, (2010/10/03)
The present invention is directed to therapeutic compotmds of the following formula (I) which have activity as agonists of GPR 119 and are useful for the treatment of metabolic disorders including type II diabetes.
