1246303-75-2

Basic information

• Product Name: t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate
• Synonyms: t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate
• CAS NO: 1246303-75-2
• Molecular Weight: 359.338
• Mol File: 1246303-75-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate(1246303-75-2)
• EPA Substance Registry System: t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate(1246303-75-2)

Safety Data

• Hazardous Substances Data: 1246303-75-2(Hazardous Substances Data)

Upstream product

• 845267-78-9 tert-butyl 2,4-dioxopiperidine-1-carboxylate 
• 33512-94-6 m-nitrobenzhydroxamoyl chloride 
• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1246303-82-1 5-(2-(N-Boc-amino)ethyl)-3-(3-nitrophenyl)isoxazole-4-carboxylic acid 
• 1365759-83-6 C₁₈H₁₈N₆O₄ 
• 1365759-77-8 C₁₂H₉N₅O₂ 
• 1365759-72-3 C₁₇H₁₇N₅O₄ 
• 1365760-33-3 C₂₇H₂₅N₇O₇ 
• 1365760-31-1 C₂₆H₂₄N₆O₄ 
• 1365760-29-7 C₂₇H₃₀N₆O₄ 
• 1365760-27-5 C₂₂H₂₂N₆O₆ 
• 1365760-24-2 C₂₄H₂₈N₆O₄ 
• 1365760-21-9 C₂₄H₂₅N₇O₄ 
• 1365760-18-4 C₂₃H₂₇N₇O₄ 
• 1365760-15-1 C₂₂H₂₄N₆O₅ 
• 1365760-12-8 C₂₁H₂₂N₆O₅ 

Relevant articles and documents

Isoxazolodihydropyridinones: 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines

Practical and efficient methods have been developed for the diversity-oriented synthesis of isoxazolodihydropyridinones via the 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines. A select few of these isoxazolodihydropyridinones were further elaborated with triazoles by copper-catalyzed azide-alkyne cycloaddition reactions. A total of 70 compounds and intermediates were synthesized and analyzed for drug likeness. Sixty-four of these novel compounds were submitted to the NIH Molecular Libraries Small Molecule Repository for high-throughput biological screening.