124643-50-1Relevant articles and documents
Sequential Silver-Catalyzed Oxidative Cyclization Reactions of Unprotected 2-Alkynylanilines to Anthranils
Arcadi, Antonio,Chiarini, Marco,Del Vecchio, Luana,Marinelli, Fabio,Michelet, Véronique
, p. 2214 - 2222 (2017)
The full details of the original Ag-catalyzed domino oxidative cyclization reactions of unprotected 2-alkynylanilines with Oxone are described. The influences of several parameters including the substrate features, oxidant, reaction conditions, and catalyst on the reaction outcome were explored. A plausible mechanism is provided for the unusual silver-catalyzed oxidative cyclization reactions of 2-alkynylanilines to anthranils.
Sonogashira cross-coupling reactions and construction of the indole ring system using a robust, silica-supported palladium catalyst
Tyrrell, Elizabeth,Whiteman, Leon,Williams, Neil
experimental part, p. 829 - 835 (2009/07/25)
The use of a recyclable silica-supported palladium catalyst in Sonogashira couplings and indole syntheses using a range of functionalised substrates is described. The catalyst is shown to be both robust and versatile, effecting the synthesis of 2-phenylindole in quantitative yield without the need for N-protection, a copper co-catalyst, a base, or a solvent. Georg Thieme Verlag Stuttgart.
PALLADIUM-CATALYSED COUPLING OF ARYL AND VINYL TRIFLATES OR HALIDES WITH 2-ETHYNYLANILINE: AN EFFICIENT ROUTE TO FUNCTIONALIZED 2-SUBSTITUTED INDOLES
Arcadi, A.,Cacchi, S.,Marinelli, F.
, p. 2581 - 2584 (2007/10/02)
The palladium(O)-catalysed coupling of aryl and vinyl triflates or halides with the easily available 2-ethynylaniline, followed by a palladium(II)-catalysed cyclization step, provides an efficient and very versatile procedure for the synthesis of function
