1248081-37-9

Basic information

• Product Name: 8-(TRIFLUOROMETHYL)-1,4-DIOXASPIRO[4.5]DECAN-8-OL
• Synonyms: 8-(TRIFLUOROMETHYL)-1,4-DIOXASPIRO[4.5]DECAN-8-OL;4-hydroxy-4-(trifluoromethyl)cyclohexanone ethylene ketal
• CAS NO: 1248081-37-9
• Molecular Formula: C₉H₁₃F₃O₃
• Molecular Weight: 226.1929296
• Mol File: 1248081-37-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-(TRIFLUOROMETHYL)-1,4-DIOXASPIRO[4.5]DECAN-8-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(TRIFLUOROMETHYL)-1,4-DIOXASPIRO[4.5]DECAN-8-OL(1248081-37-9)
• EPA Substance Registry System: 8-(TRIFLUOROMETHYL)-1,4-DIOXASPIRO[4.5]DECAN-8-OL(1248081-37-9)

Safety Data

• Hazardous Substances Data: 1248081-37-9(Hazardous Substances Data)

Usage

General Description

8-(Trifluoromethyl)-1,4-dioxaspiro[4.5]decan-8-ol is a chemical compound with a spiro structure containing a trifluoromethyl group. It is a white solid at room temperature and is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its spiro structure and fluorine substitution make it a valuable intermediate for the development of new compounds with potential biological activity. The presence of the hydroxyl group also provides reactivity for further functionalization, making it a versatile and useful compound in organic synthesis. Despite its potential applications, caution should be exercised when handling this compound, as it may pose hazards if not used appropriately.

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 75092-00-1 4-(trifluoromethyl)cyclohexanone (2,4-dinitrophenyl)hydrazone 
• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 
• 120929-90-0 4-hydroxy-4-(trifluoromethyl)cyclohexan-1-one 
• 1202411-98-0 4-amino-1-(trifluoromethyl)cyclohexan-1-ol 
• 1346555-40-5 4-(cyclopropylamino)-1-(trifluoromethyl)cyclohexanol 
• 1346555-38-1 N-cyclopropyl-N-((1r,4r)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-6-(piperidin-1-yl)picolinamide 
• 1346554-38-8 N-cyclopropyl-N-((1s,4s)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-6-(piperidin-1-yl)picolinamide 

Relevant articles and documents

COMPOUNDS USEFUL AS KINASE INHIBITORS

This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK).The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of Bruton's tyrosine kinase, for example cancer, lymphoma, leukemia and immunological diseases.

SUBSTITUTED 3-(BIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE

The invention relates to substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-ones, in particular for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of neoplastic disorders.

Spectroscopic and X-ray crystallographic evidence for electrostatic effects in 4-substituted cyclohexanone-derived hydrazones, imines, and corresponding salts

The axial conformer of several 4-substituted cyclo-hexanone hydrazone salts was found to predominate in solution. Changes in the charge of the molecule and the polarity of the solvent led to changes in the conformational preference of each molecule that were consistent with electrostatic stabilization of the axial conformer. H NMR spectroscopic analysis was utilized to determine the structure of cyclohexanone-derived substrates by comparison to conformationally restricted trans-decalone derivatives and computational models. X-ray crystallography demonstrated that the axial configuration of a pendant benzyloxy group is the preferred conformation of an iminium ion in the solid state. The structure of a neutral hydrazone was also determined to favor the axial configuration for a pendant benzyloxy group in the solid state.