1248340-80-8

Basic information

• Product Name: 7-chloro-5-methyl-2-phenylbenzo[b]furan
• Synonyms: 7-chloro-5-methyl-2-phenylbenzo[b]furan
• CAS NO: 1248340-80-8
• Molecular Weight: 242.705
• Mol File: 1248340-80-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-chloro-5-methyl-2-phenylbenzo[b]furan(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-5-methyl-2-phenylbenzo[b]furan(1248340-80-8)
• EPA Substance Registry System: 7-chloro-5-methyl-2-phenylbenzo[b]furan(1248340-80-8)

Safety Data

• Hazardous Substances Data: 1248340-80-8(Hazardous Substances Data)

Upstream product

• 1335094-09-1 2-chloro-6-iodo-4-methylphenol 
• 536-74-3 phenylacetylene 
• 106-44-5 p-cresol 
• 6640-27-3 2-chloro-p-cresol 
• 1248340-83-1 1-(3-chloro-2-hydroxy-5-methylphenyl)-2-chloroethanone 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 1335094-25-1 5-methyl-2-phenyl-7-(thiophen-3-yl)benzo[b]furan 
• 1335094-22-8 7-(4-methoxyphenyl)-5-methyl-2-phenylbenzo[b]furan 
• 1335094-23-9 C₂₇H₂₀O 
• 1335094-21-7 7-(3-carbomethoxyphenyl)-5-methyl-2-phenylbenzo[b]furan 
• 1335094-24-0 7-(4-fluoro-3-methylphenyl)-5-methyl-2-phenylbenzo[b]furan 
• 1422250-97-2 N-(5-methyl-2-phenylbenzo[b]furan-7-yl)piperidin-1-amine 
• 1422250-96-1 1,1-dimethyl-2-(5-methyl-2-phenylbenzo[b]furan-7-yl)hydrazine 
• 1422250-95-0 1-ethyl-4-(5-methyl-2-phenylbenzo[b]furan-7-yl)piperazine 
• 1422250-94-9 1-(4-fluorophenyl)-4-(5-methyl-2-phenylbenzo[b]furan-7-yl)piperazine 
• 1422250-93-8 4-(5-methyl-2-phenylbenzo[b]furan-7-yl)morpholine 
• 1335094-32-0 1-(5-methyl-2-phenylbenzo[b]furan-7-yl)piperidine 

Relevant articles and documents

Multisubstituted benzo[b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process

Full details as well as the study of the scope, limitations, and further elaboration of a straightforward approach to the synthesis of 2,5,7-trisubstituted benzo[b]furans from 2-bromo- and 2-chloro-6-iodo-4- substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process is described. Functionalization at the C(7) position is carried out by Suzuki-Miyaura cross-coupling, alkynylation, alkenylation, and C-N bond forming reactions. A one-pot protocol for the synthesis of 2,5,7-trisubstituted benzo[b]furans is also reported.

Controlled synthesis of 2-and 3-substituted benzo[ b ]furans

A controlled regioselective synthesis of either C-2 or C-3 substituted benzo[b]furans from readily accessible 1-(2-hydroxyphenyl)-2-chloroethanones is described. Addition of a range of Grignard reagents to the α-chloro ketones generates alkoxide intermediates, which can form either 2-substituted benzo[b]furans via a [1,2]-aryl migration or 3-substituted benzo[b]furans via a direct cyclization and dehydration sequence. A temperature-dependent [1,2]-aryl migration mechanism for the formation of 2-substituted benzo[b]furan is proposed.