124908-16-3Relevant articles and documents
AIBN-initiated direct thiocyanation of benzylic sp3C-H with: N -thiocyanatosaccharin
Wu, Di,Duan, Yongjie,Liang, Kun,Yin, Hongquan,Chen, Fu-Xue
supporting information, p. 9938 - 9941 (2021/10/12)
Direct thiocyanations of benzylic compounds have been implemented. Here, a new strategy, involving a free radical reaction pathway initiated by AIBN, was used to construct the benzylic sp3 C-SCN bond. In this way, the disadvantage of other strategies involving introducing leaving groups in advance to synthesize benzyl thiocyanate compounds was overcome. The currently developed protocol also involved the use of readily available raw materials and resulted in high product yields (up to 100%), both being great advantages for synthesizing benzyl thiocyanates.
Preparation method for alpha-benzene methane sulfonic acid derivative with optical activity
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Paragraph 0049-0056, (2018/04/01)
The invention discloses a preparation method for alpha-benzene methane sulfonic acid derivative with optical activity. The preparation method comprises the following steps: Step A: mixing a sodium thiocyanate aqueous solution with compound (I) to react, carrying out postprocessing after reaction is finished to obtain a compound (II); Step B: mixing the compound (II), acetic acid and concentrated sulfuric acid, carrying out oxidation reaction after hydrogen peroxide is added, and carrying out postprocessing after reaction is finished to obtain the alpha-benzene methane sulfonic acid derivative. According to the preparation method, the sodium thiocyanate is adopted as an reaction reagent, reaction yield is effectively improved, and meanwhile, preparation method is simple in operation, is friendly to environment and is easy in carrying out industrial production.
A simple, one-pot and phosphine-free procedure for thiocyanation of alcohols Using N-(p-toluenesulfonyl) imidazole (TsIm)
Rad, Mohammad Navid Soltani
, p. 583 - 587 (2016/10/18)
An efficient, one-pot, phosphine-free thiocyanation of alcohols has been achieved utilising potassium thiocyanate and N-(p-toluenesulfonyl) imidazole (TsIm) as a coupling agent in the presence of triethylamine in anhydrous DMF at 70 °C. This method converts primary alcohols into the corresponding thiocyanates, without isomerisation to isothiocyanates, in good to excellent yields. A total of 17 thiocyananates were prepared, five of which are novel. Using one equivalent of KSCN, the method shows good selectivity in the thiocyanation of a primary alcohol in the presence of a secondary alcohol.