125198-40-5 Usage
Description
Mycophenolic Acid Cyclopropane Analogue is a non-active analogue of Mycophenolic Acid, an antibiotic derived from certain species of Penicillium fungi. It is characterized by its unique cyclopropane structure, which distinguishes it from the parent compound. This analogue exhibits selective inhibition of lymphocyte proliferation by targeting inosine monophosphate dehydrogenase, a key enzyme in the de novo synthesis of purine nucleotides.
Uses
Used in Pharmaceutical Industry:
Mycophenolic Acid Cyclopropane Analogue is used as a research tool for studying the mechanisms of action and potential applications of Mycophenolic Acid in various therapeutic areas. Its non-active nature allows for the investigation of the parent compound's effects without the confounding influence of its biological activity.
Used in Immunosuppressive Applications:
Although the analogue itself is non-active, it serves as a valuable reference in the development of immunosuppressive drugs. Mycophenolic Acid, the parent compound, is known for its immunosuppressive properties, making it a potential candidate for the treatment of autoimmune diseases and organ transplant rejection.
Used in Drug Design and Synthesis:
Mycophenolic Acid Cyclopropane Analogue can be utilized in the design and synthesis of novel compounds with improved pharmacological properties. By understanding the structural differences between the analogue and the parent compound, researchers can potentially develop new drugs with enhanced efficacy and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 125198-40-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,1,9 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 125198-40:
(8*1)+(7*2)+(6*5)+(5*1)+(4*9)+(3*8)+(2*4)+(1*0)=125
125 % 10 = 5
So 125198-40-5 is a valid CAS Registry Number.
125198-40-5Relevant articles and documents
Synthesis and immunosuppressive activity of some side-chain variants of mycophenolic acid
Nelson,Eugui,Wang,Allison
, p. 833 - 838 (2007/10/02)
The syntheses and immunosuppressive bioassays of 12 side-chain variants of mycophenolic acid (1a) are described. The compounds were made either from mycophenolic acid itself or from 5-(chloromethyl) -1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran (3), a versatile intermediate for the synthesis of diverse side-chain variants. Replacement of the methylated E double bond of the natural product with a triple bond, a Z double bond, a saturated bond, or a sulfur atom, with overall chain lengths equal to or greater than that of mycophenolic acid, produced compounds devoid of significant activity. Replacement of the side-chain double bond with difluoro, dibromo, or unsubstituted cyclopropane rings also removed most activity. Replacement of the double bond with an allenic linkage yielded a compound with about one-fifth of the immunosuppressive activity of mycophenolic acid. Some possible causes for the unusual specificity of structure and activity are discussed.
