1254049-66-5

Basic information

• Product Name: 6-ethyl-5-[(1-methylpiperidin-3-yl)amino]-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide
• Synonyms: 6-ethyl-5-[(1-methylpiperidin-3-yl)amino]-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide
• CAS NO: 1254049-66-5
• Molecular Weight: 432.547
• Mol File: 1254049-66-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-ethyl-5-[(1-methylpiperidin-3-yl)amino]-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ethyl-5-[(1-methylpiperidin-3-yl)amino]-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide(1254049-66-5)
• EPA Substance Registry System: 6-ethyl-5-[(1-methylpiperidin-3-yl)amino]-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide(1254049-66-5)

Safety Data

• Hazardous Substances Data: 1254049-66-5(Hazardous Substances Data)

Upstream product

• 35216-39-8 3-(methylsulfonyl)aniline 
• 42389-57-1 3-amino-1-methylpiperidine 
• 1254057-77-6 5-chloro-6-ethyl-3-[3-(methanesulfonyl)anilino]pyrazine-2-carboxamide 
• 313340-08-8 3,5-dichloro-6-ethylpyrazine-2-carboxamide 

Relevant articles and documents

DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND

Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein. As a result of intensive and extensive studies on compounds having inhibitory activity against the kinase activity of EML4-ALK fusion protein, the present inventors found that the diamino heterocyclic carboxamide compounds of the present invention had inhibitory activity against the kinase activity of EML4-ALK fusion protein. By this finding, the present invention was completed. The compounds of the present invention can be used as a pharmaceutical composition for preventing and/or treating cancer, such as lung cancer, non-small cell lung cancer, and small cell lung cancer.