125483-00-3

Basic information

• Product Name: 3-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID
• Synonyms: 3-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID;Benzoic acid, 3-amino-4-(trifluoromethyl)- (9CI);3-Amino-4-(trifluoromethyl)benzoic acid 98%;3-Amino-4-(trifluoromethyl)benzoicacid98%;5-Carboxy-2-(trifluoromethyl)aniline, 2-Amino-4-carboxybenzotrifluoride
• CAS NO: 125483-00-3
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.13
• Product Categories: AMINOACID;Benzoic acid;Fluorine series
• Mol File: 125483-00-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 203-205°C
• Boiling Point: 325.4 °C at 760 mmHg
• Flash Point: 150.6 °C
• Appearance: /
• Density: 1.489
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.85±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID(125483-00-3)
• EPA Substance Registry System: 3-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID(125483-00-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 125483-00-3(Hazardous Substances Data)

Usage

General Description

3-Amino-4-(trifluoromethyl)benzoic acid is an organic compound with the chemical formula C8H6F3NO2. It is a white crystalline solid with a molecular weight of 199.1 g/mol. 3-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It contains an amino group, a trifluoromethyl group, and a carboxylic acid group, making it a versatile building block for various chemical reactions. It is also used in the production of dyes and pigments, as well as in the synthesis of complex organic molecules. 3-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID is considered to be of low toxicity and is not known to pose significant health hazards to humans.

Upstream product

• 116965-16-3 3-nitro-4-(trifluoromethyl)benzoic acid 
• 455-24-3 4-trifluoromethylbenzoic acid 

Downstream Products

• 126541-80-8 3-Acetamino-4-(trifluormethyl)benzoesaeure 
• 126541-87-5 3-hydroxy-4-trifluoromethylbenzoic acid 
• 126541-84-2 C₁₆H₈F₆N₂O₅ 
• 126541-88-6 3-Hydroxy-4-(trifluormethyl)benzoesaeure-methylester 
• 126542-07-2 5-Hydroxy-2-nitro-4-trifluoromethyl-benzoic acid 
• 126541-93-3 3-Hydroxy-2-nitro-4-(trifluormethyl)benzoesaeure 
• 126541-89-7 3-Hydroxy-2-nitro-4-(trifluormethyl)benzoesaeure-methylester 
• 126541-90-0 3-Hydroxy-6-nitro-4-(trifluormethyl)benzoesaeure-methylester 
• 126541-83-1 3-Acetamino-6-nitro-4-(trifluormethyl)benzoesaeure 
• 126541-94-4 N-[3-Hydroxy-4-(trifluormethyl)benzoyl]-L-threonin-methylester 
• 126542-00-5 N-<3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl>-L-threonin 
• 128995-23-3 N-<3-Hydroxy-6-nitro-4-(trifluormethyl)benzoyl>-L-threonin-methylester 
• 126541-95-5 N-[3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl]-L-threonin-methylester 
• 126541-85-3 4,4'-Bis(trifluormethyl)-3,3'-azoxydibenzoesaeure-dimethylester 

Relevant articles and documents

TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S

Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.