125697-63-4

Basic information

• Product Name: 2,5-Dioxopyrrolidin-1-yl 6-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)hexanoate
• Synonyms: 2,5-Dioxopyrrolidin-1-yl 6-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)hexanoate
• CAS NO: 125697-63-4
• Molecular Formula: C₂₅H₂₆N₂O₆
• Molecular Weight: 450.48374
• Mol File: 125697-63-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,5-Dioxopyrrolidin-1-yl 6-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)hexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dioxopyrrolidin-1-yl 6-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)hexanoate(125697-63-4)
• EPA Substance Registry System: 2,5-Dioxopyrrolidin-1-yl 6-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)hexanoate(125697-63-4)

Safety Data

• Hazardous Substances Data: 125697-63-4(Hazardous Substances Data)

Usage

General Description

2,5-Dioxopyrrolidin-1-yl 6-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)hexanoate is a chemical compound that contains a pyrrolidinone ring and a fluorenyl group. It is a derivative of pyrrolidinone with a hexanoic acid ester at the 1-position and a carboxybenzene-9-yl group at the 6-position. This chemical is often used in pharmaceutical applications due to its potential as a drug delivery agent or as part of a biologically active molecule. The compound's specific structure and properties make it suitable for use in drug development and research.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 88574-06-5 6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid 

Downstream Products

• 32795-70-3 (5-aminopentylcarboxamido)-L-thyroxine 
• 1609106-32-2 3-(2-{[N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)glycyl]amino}phenyl)propanoic acid 
• 1609106-33-3 9H-fluoren-9-ylmethyl{6-[(2-{[2-(3-{[(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)sulfonyl]amino}-3-oxopropyl)phenyl]amino}-2-oxoethyl)amino]-6-oxohexyl}carbamate 
• 1609106-34-4 9H-fluoren-9-ylmethyl (6-{[2-({2-[3-({[4-(aminomethyl)phenyl]sulfonyl}amino)-3-oxopropyl]phenyl}amino)-2-oxoethyl]amino}-6-oxohexyl)carbamate 

Relevant articles and documents

Development of a fluorescent cardiomyocyte specific binding probe

Cardiomyocytes are the major component of the heart. Their dysfunction or damage could lead to serious cardiovascular diseases, which have claimed numerous lives around the world. A molecule able to recognize cardiomyocytes would have significant value in diagnosis and treatment. Recently a novel peptide termed myocyte targeting peptide (MTP), with three residues of a non-natural amino acid biphenylalanine (Bip), showed good affinity to cardiomyocytes. Its selectivity towards cardiac tissues was concluded to be due to the ability of Bip to bind cardiac troponin I. With the aim of optimizing the affinity and the specificity towards cardiac myocytes and to better understand structure-activity relationship, a library of MTP derivatives was designed. Exploiting a fluorescent tag, the selectivity of the MTP analogs to myocardium over skeletal and stomach muscle tissues was assayed by fluorescence imaging. Among the tested sequences, the peptide probe Bip2, H-Lys(FITC)-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Ser-Gly-Ser-Bip-Bip-NH2, displayed the best selectivity for cardiomyocytes.

PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS

Photoactive probes and probe systems for detecting biological interactions are described. The photoactive probes include probes that combine both photocleavable and photoreactive moieties. The photoactive probe systems can include a first probe comprising a photocatalytic group and a second probe comprising a group that can act as a substrate for the reaction catalyzed by the photocatalytic group. The probes and probe systems can also include groups that can specifically bind to a binding partner on a biological entity of interest and a detectable group or a precursor thereof. The probes and probe systems can detect spatiotemporal interactions of proteins or cells. In some embodiments, the interactions can be detected in live cells. Also described are methods of detecting the biological interactions.

A novel strategy for bioconjugation: Synthesis and preliminary evaluation with amphotericin B

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